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Table 2 Summary of the included systematic reviews

From: An evidence mapping of systematic reviews and meta-analysis on traditional Chinese medicine for ulcerative colitis

No. Study ID (first author, year) Interventions Review objectives (quote from the original paper) Population Intervention (TCM used) Comparator Number of studies
1 Gong Y2014 Decoction To evaluate the efficacy and safety of Sishen Pill in the treatment of UC. n = 839 Sishen Pills SASP, Gubenyichang Tablets, Bupiyichang Pill, Hydrocortisone 10 RCTs
2 Li WH2013 Decoction To evaluate the efficacy and safety of Pulsatilla Decoction for UC. n = 1124 Pulsatilla Decoction SASP 10 RCTs
3 Zuo HB2013 Decoction To evaluate the efficacy and safety of Pulsatilla Decoction for UC. n = 1480 Pulsatilla Decoction SASP, 5-ASA, Hormone preparation 12 RCTs
4 Pei QW2012 Decoction To evaluate the effectiveness and safety of Jiajian Banxia Xiexin decoction forUC. n = 736 Banxia Xiexin Decoction, Danggui Shaoyao Powder, Taohong Siwu Decoction SASP, Bifico, Hormone preparation, Mesalazine 8 RCTs
5 Wen Y2017 Decoction, Chinese patent medicine To make a Meta-analysis of the effectiveness and safety of Shenling Baizhu Powder for the treatment of UC, thus to provide evidence for the clinical treatment of UC. n = 1498 Shenling Baizhu Powder SASP, Mesalazine, Hormone preparation, Osalazine 19 RCTs
6 Chen K2016 Chinese patent medicine Generally evaluate the therapeutic effect of Shenling Baizhu Powder combined with Western Medcine on UC. n = 884 Shenling Baizhu Powder SASP, Mesalazine 10 RCTs
7 Lu2017 Chinese patent medicine To evaluate the clinical efficacy and safety of Shenling Baizhu powder in the treatment of UC by means of evidence-based medicine. n = 1736 Shenling Baizhu Powder Mezalazine, SASP, Metronidazole, Osalazina 20 RCTs
8 Wang XY2017 Chinese patent medicine To evaluate the clinical efficacy and safety of Shenling Baizhu Powder in the treatment of UC. n = 1041 Shenling Baizhu Powder SASP, Mesalazine 12 RCTs
9 Wei Y2018 Decoction, Chinese patent medicine To evaluate the clinical efficacy of retention enema with TCM in the treatment of UC. n = 1447 Baishao Qiwu Granule, Changyankang I, Compound Xuejie Enema on the Blood Rheology, Colon soup, Kuijie enema, Lianbei Mixture, Qingjie Qushi Decoction, Shibai Shenbai Decoction SASP, Hormones, gentamicin, dexamethasone, furazolidone, montmorillonite powder,smecta 16 RCTs
10 Zhang LH2018 Decoction, Chinese patent medicine To evaluate Fuzilizhong decoction and its modified decoction systematically and summarize the clinical efficacy and safety of the treatment of UC. n = 688 Fuzi Lizhong decoction, Sishen Pill, Kangfuxin solution SASP, Kangfuxin 8 RCTs
11 Li HB2017 Chinese patent medicine To systematically evaluate the clinical efficacy and safety of Compound Huangbo liquid combined with chemical medicine in the treatment of UC, and to provide evidence-based reference n = 737 Compound Huangbo liquid, Mezalazine SASP, Mezalazine, 5-ASA, Hormones, immunosuppressants, physiological saline 8 RCTs
12 Li HB2018 Chinese patent medicine To systematically evaluate therapeutic efficacy and safety of Compound kushen colon-release capsule versus related chemical drugs in treatment of UC. n = 649 Compound kushen colon-release capsule SASP, Mezalazine, placebo 9 RCTs
13 Huang FMZ2014 Decoction To evaluate the efficacy of JieDuXiaoYongFa and the variation of relevant indicators compared to conventional medicine for the treatment of UC. n = 1884 NR SASP, Mezalazine, Hormones, Gentamicin, Penicillin, Smecta 23 RCTs
14 Li HB-a2018 Chinese patent medicine To systematically evalutate the clinical efficacy of Kangfuxin Liquid versus aminosalicylic acid in treating UC, in order to provide scientific basis for clinical promotion. n = 806 Kangfuxin Liquid SASP, 5-ASA, Folic acid, Metronidazole 9 RCTs
15 Liu G2011 Chinese patent medicine To evaluate the effect of the treatment based on Kangfuxin liquid in UC. n = 607 Kangfuxin Liquid NR 8 RCTs
16 Gu SZ2018 Decoction, Chinese patent medicine To systematically evaluate the efficacy and safety of the RCT of oral Chinese medicine for the treatment of UC. n = 1703 Kuijie Decoction, Changyankang, Jianpi Yuchang Decoction, Qingchang Huashi Decoction, Sijunzi Decoction, Xianglian Zhixie Tablet, Wenjing Decoction, Juyuan Decoction, Wumei Pill, Qingre Lishi Recipe, Baiji Yukui Decoction, Changqingshu Decoction, Jianpi Huazhi Pill, Kuijiening, Zhenren Yangzang Decoction, Wenshen Jianpi Decoction, Wenyang Yuyang Decoction, Fuzheng Quxie Decoction. SASP, Mezalazine 20 RCTs
17 Xiong AQ2011 Decoction Objective evaluation of the treatment of UC with TCM. n = 582 Wumei Baijiang Decoction, Shaoyao Decoction, Jianpi Decoction, Qingchang Yuyang Decoction, Qingchang Liangxue Decoction, Sijunzi Decoction, Tongxieyao Decoction, Jianpi Qushi Huazhuo Decoction. Mezalazine 8 RCTs
18 Lv C2014 NR To evaluate the efficacy and safety of clearing away intestinal dampness and heat methods on UC. n = 1797 NR SASP, Mezalazine, Metronidazole, Osalazina 20 RCTs
19 Wang DY2011 Decoction, Chinese patent medicine To evaluate heat spleen with wet method in active treatment the curative effect of UC and security, to reveal the advantages of the method in active treatment of UC activity for TCM treatment of UC to provide the basis of evidence-based medicine. n = 2641 Anchang Zhixie Decoction, Shenling Baizhu Decoction, Changyuning Granule, Gegen Qinlian Decoction, Kuijie Decoction, Lipi Yuyang Decoction, Baitouweng Decoction, Mankuining, Qinghua Changyin SASP, Mezalazine, Hormones, Smecta,Metronidazole, Gentamicin, Placebo 36 RCTs
20 Liu TW2016 Decoction To explore the effectiveness and safety of Paeoniae decoction in the treatment of UC. n = 1181 Shaoyao Decoction BaWei XiLei Powder, SASP, Metronidazole, berberine, hydrocortisone, oxalazine, hormones 17 RCTs
21 Yang L2017 Decoction To evaluate the efficacy of Shaoyao Decoction in the therapy of UC. n = 637 Shaoyao Decoction SASP, Mezalazine 9 RCTs
22 Zhang WN2017 Decoction, Oitment To evaluate the efficacy of Tongxie Yaofang in the therapy of UC. n = 696 prescription for treating diarrhoea with abdominal pain, Baizhu Shaoyao Powder, Changyanling SASP, Probiotics, Norfloxacin, Vitamin, Smecta 8 RCTs
23 Chen F2012 Decoction To evaluate the kidney and spleen method in the treatment of remission of UC efficacy and safety. n = 2928 Wenyang Yiqi Jiedu Decoction, Wumei Pill, Zhenpi Decoction, Huangqi Jianzhong Decoction, Bupi Yichang Decoction, Wenshen Hezhong Decoction, Fuzi Lizhong Decoction, Sishen Pill, Shenling Baizhu Powder, Buzhong Yiqi Decoction, Lizhong Decoction, Kuijieling, Xileisan, Qiwei Baizhu Powder, Jianpi Yishen Formula, Jiechang Kang, Wenbu Zhixie Decoction, Weichangning Decoction, Huangtu Decoction, Jianpi Lichang Decoction, Tiaozhong Lichang Decoction, Jiedu Shengji Decoction, Lianli Decoction and Zhenren Yangzang Decoction SASP, Mezalazine, Xileisan, Smecta, Norfloxacin, Hormone, Gentamicin 35 RCTs
24 Yan SG2013 Decoction To evaluate the efficacy of Wumei Pill in the therapy of UC. n = 1170 Wumei Pill SASP, Bupi Yichang Pill, Amoxicillin 10 RCTs
25 Xiong J2008 Decoction To evaluate the efficacy of Wumei Pill in the therapy of UC. n = 1159 SASP, Wumei Pill, Zhenren Yangzang Decoction, Qiwei Baizhu, Liujunzi Decoction, Sishen Pill SASP, Hormone 10 RCTs
26 Chen MY2018 Chinese patent medicine To systematically evaluate the clinical efficacy and safety of Xilei Powder compared with mesalamine in the treatment of UC. n = 373 Xilei Powder Mezalazine 6 RCTs
27 Chen MY2018-a Chinese patent medicine Meta-analysis of Xileisan combined with Mesalazine in the treatment of UC. n = 840 Xilei Powder SASP, Hormone 12 RCTs
28 Cui DJ2012 Chinese patent medicine To evaluate the efficacy and safety of Xilei powder on UC. n = 83 Xilei Powder Mezalazine 2 RCTs
29 Ma XM2012 Chinese patent medicine To systematically evaluate the clinical efficacy of Xileisan in the treatment of UC. n = 1476 Xilei Powder SASP, 5-ASA, Smecta, Hormone, Antibiotic 21 RCTs
30 Lai YL2013 Decoction To evaluate the clinical efficacy of TCM with Xinkai Kujiang method in the treatment of UC. n = 551 Wumei Pill, Lianli Wumei Decoction, Chaigui Ganjiang Decoction SASP, Mezalazine 9 RCTs
31 Zhu JB2016 Decoction To make a systematic review on the clinical effect and safety of modifiedBanxia Xiexin Decoction in the treatment of UC. n = 1200 Banxia Xiexin Decoction NR 14 RCTs
32 Huang ZB2014 Chinese patent medicine To systematically evaluate the effectiveness of Yunnan Baiyao in treating UC. n = 1463 Yunnan white Drug SASP, 5-ASA 20 RCTs
33 Qi J2016 Decoction To evaluate the clinical efficacy of Zhenren Yangzang Decoction in the treatment of UC. n = 209 Zhenren Yangzang Decoction SASP 3 RCTs
34 luo Y2012 NR Evaluation the efficicy and safety about the Chinese and Western method of treatment on UC. n = 7740 NR NR 113 RCTs
35 Xu P2015 Decoction, Chinese patent medicine 1 To sum up the results of the RCT about the treatments of UC with integrative medicine.2 Using Mete-analysis methods to evaluate the effectiveness,safety and the rates of recurrence,in order to provide reference and guidance for clinical treatment of UC. n = 1696 Pulsatilla Decoction, Kangfuxin Liquid, Hongteng Decoction, Puqin Baijiang Decoction conventional medicine 20 RCTs
36 Gong YD2012 NR Evaluate wether conventional medicine combined TCM therapy more advantageous than simple Western medicine therapy. n = 1897 NR conventional medicine 16 RCTs
37 Ma DZ2015 NR Comprehensive evaluation of the clinical efficacy of retention enema with TCM in the adjuvant treatment of UC. n = 1358 NR conventional medicine 18 RCTs
38 Huang SG2010 Decoction, Chinese patent medicine Applying the method of Meta-Analysis, generally evaluation the therapeutic effect of retention-enema of Chinese herb treating UC. n = 875 Danshen enema, Hongteng mixture, Kuju solution, Kuijieqing enema, Huangqi Decoction, Baitouweng Decoction SASP, Hormone, Antibiotic, Sulfamethoxazole 7 RCTs
39 Ni XX2019 Decoction, Chinese patent medicine To systematically evaluate the efficacy and safety of retention enema with Chinese materia in the treatment of UC. n = 3110 Yunnan white Drug, Xilei Powder, Qibei Mixture, Zhikang Capsule, Shenling Baizhu Powder conventional medicine 36 RCTs
40 Jiang T2006 NR To assess the theraoeutic effectiveness of retention enema with TCM in the treatment of UC. n = 2092 NR SASP, Hormone, Antibiotic 23 RCTs
41 Zhu XG2012 Decoction, Chinese patent medicine Comprehensive evaluation of clinical efficacy of retention enema with TCM in the treatment of UC. n = 1584 Yunnan White Drug, Jiechang Decoction, Kuijiekang, Kuju Liquid, Yuchang Zhengchang Decoction, Tongguan Decoction, Yasanzi Sanhuang Decoction, Hongteng Mixture, Yuyang Anchang Decoction, Danshen enema Liquid, Xilei Liquid, Kuijieqing enema Liquid, Pulsatilla Decoction, Huangqi Decoction. SASP, Hormone, Antibiotic, Smecta, Sulfamethoxazole compound 15 RCTs
42 You WF2017 NR Quantitative analysis of clinical efficacy of retention enema of TCM for UC based on evidence-based medicine methodology. n = 988 NR NR 7 RCTs
43 Cui DJ-a2012 Chinese patent medicine To evaluate the efficacy and safety of Bupi Yichang Pill in the therapy of UC. n = 596 Bupi Yichang Pill SASP, Mezalazine, balsalazide 6 RCTs
44 WuZl2017 Decoction, Chinese patent medicine To evaluate the therapeutic effect of TCM enema combined with mesalazine in treating UC. n = 1521 Changkui Decoction, Qingchang Huashi Decoction, Qingchang Yuyang Decoction, Shenling Baizhu Powder and Baitouweng Decoction Mezalazine 22 RCTs
45 Huang HJ2012 NR The objective of this study was to systematicly ewduate the clinical therapeutic effcct of Chinese materia medica and western drugs used in retention enema for treating UC. n = 476 NR NR 5 RCTs
46 Zha AS2015 NR The aim of this study was to evaluate the safety and efficacy of Huoxue Huayumethod of TCM in the treatment of UC. n = 1897 NR Mezalazine, SASP, Hormones, Antibiotics, Metronidazole 20 RCTs
47 Hou LW2017 Decoction To review systematically the therapeutic effects and safety on UC treated with the oral administration and enema with TCM n = 1507 Tiaoqi Jiedu Decoction, Yuchang Decoction, Shenling Baizhu Powder, Gegen Qinlian Decoction, Shaoyao Decoction, Changyan Decoction, Jianpi Lichang Decoction, Self-made Xiaoulcer, Gegen Qinlian Wutan Decoction SASP, Hormones, Ampicillin 18 RCTs
48 Hou LW2015 Decoction, Chinese patent medicine To systematically evaluate clinical efficacy of oral medicine decoction with enema treatment of UC. n = 856 Colon Ning Mixture, Yuyangning Decoction, Tongxie Yaofang, Shenling Baizhu Powder, Shaoyao Decoction, Gegen Qinlian Decoction, Gegen Qinlian Wutan Decoction SASP, Hormones, Antibiotic 11 RCTs
49 Gan YK2015 Decoction To evaluate the efficacy of TCM for oral compared with Mesalazine in thetreatment of UC through meta-analysis. n = 543 Changqingshu Decoction, Sijunzi Decoction and Tongxie Decoction, Qingchang Yuyang Decoction, Wumei Baicai Decoction, Jianpi Decoction, Qingchang Liangxue Decoction, Jianpi Qushihuo Decoction Mezalazine 7 RCTs
50 Zhu JM2011 NR To evaluate the clinical efficacy of Chinese medicine treatment on UC. n = 2702 NR SASP, Basalazide, Mesalazine, Smecta, Antibiotics, Hormones, Vitamins 33 RCTs
51 Wang DY2013 Decoction, Chinese patent medicine To evaluate the curative effect and safety of TCM Heat-Clearing and Damp-Excreting and Spleen-Strengthening Method for the treatment of active UC. n = 896 Modified Yuyang Decoction, Huangqi Jianzhong Decoction, Huoxue Lichang Decoction, Jianpi Lishi Decoction, Kuijieling No. 1, Qibaiyichang Decoction, Qini Yuyang Decoction, Baitouweng Decoction, Kuijiefukang Decoction, Qingre Lishi Yichang Decoction, Baitouweng Decoction, Liuhe Decoction, Jianpiyukui Decoction, Chinese Herbal Enema Prescription SASP, Smecta, Hormone, Ciprofloxacin 13 RCTs
52 Wang Y2018 NR To evaluate the regulation of gut flora in patients with UC on TCM. n = 392 NR SASP, Mezalazine 5 RCTs
53 He M2007 NR Comparing the clinical efficacy of TCM preparation and SASP in the treatment of UC. n = 611 NR SASP 7 RCTs
54 Pei QW2013 Decoction, Chinese patent medicine To evaluate the effectiveness and safety of method of chinese herbs oral therapy for treating UC. n = 1923 Tongxiening Granule, Fuling Powder, Wumei Pill, Mahuang Fuzi Xixin Decoction, Compound Kushen Colon-dissolving Capsule, Xuefu Zhuyu Decoction, Shaoyao Decoction, Kuijie Recurrent Decoction, Ulcer Powder, Zhuche Pill, Guipi Decoction, Changpikang, Qixian Anchang Decoction, Jianpi Zaoshi Decoction, Kuijietong Decoction, QinGeng Chunpi Decoction Liquor, Coix Root and Fructus Aconiti Patriniae Powder, Changyankang Oral Liquid, Warming Spleen Decoction, Banxia Xiexin Decoction, Danggui Shaoyao Powder, Taohong Siwu Decoction, Qiwei Baizhu Powder SASP, Hormones, Oxalazine, Folic acid, miya, Mesalazine 23 RCTs
55 Yang AX2006 NR To compare clinical therapeutic effects of simple TCM and simple conventional medicines on UC. n = 1237 NR NR 11 RCTs
56 Zhu L2012 NR To compare clinical therapeutic effects of simple TCM and 5-ASA on UC. n = 739 NR NR 11 RCTs
57 Jia JW2019 Decoction, Chinese patent medicine Systematic evaluation of the clinical efficacy of TCM retention enema in the treatment of UC. n = 1450 Colon Qingfang, Kuijie Enema Decoction, Qingre Jiedu Decoction, Ulcer Powder, Sanqi Zicao Decoction, Diyu Charcoal with Baiji, Sanhuang Decoction, Kuijie Decoction, Baishao Licorice Decoction SASP, Metronidazole, Dexamethasone, Hydrocortisone, Mesalazine, Gentamicin, Tinidazole, Gentamicin sulfate, Oxalazine 16 RCTs
58 Li L2019 Decoction Systematic evaluation of the efficacy and safety of TCM for clearing away heat and dampness combined with conventional medicine in the treatment of UC. n = 1176 Bai Tou Weng Decoction, Qingluo Huachang Decoction, Gegen Qinlian Decoction, Yiqi Qingchang Decoction, Baitouweng plus Gancao and Ejiao Decoction, Shaoyao Decoction, Qingchang Powder, Qingchi Powder, Qingre Changyu Decoction, Yu Chang Ning capsule, Kuiyu Decoction SASP, Mezalazine 15 RCTs
59 Chen MJ2019 Decoction, Chinese patent medicine To systematically evaluate clinical effects of proprietary Chinese medicine containing
Sophora Flavescens on UC.
n = 883 Composite Sophora Colon-soluble Capsules, Kuh-seng Injection, Kuh-seng enema, Tongguan liquid, Baihe and Kuh-seng enema, Kuh-seng Huaihua mixture SASP, Mezalazine 9 RCTs
60 Wu N2019 Decoction Systematic evaluation of the efficacy and safety of Huangqin Decoction in UC. n = 777 Huangqin Decoction SASP, Mezalazine, Probiotics 10 RCTs
61 Peng JF2019 Decoction, Chinese patent medicine To evaluate the therapeutic effect of TCM retention enema in treating UC. n = 2477 Colon An Liquid, Yuanxing Changan Liquid, Shengji Powder, Xihuang Mixture, Kuijie Powder, Huanglian Decoction, Xilei Powder, Kangfuxin Liquid, Pearl Guchang Powder, Jiaodai Decoction SASP, Mesalazine 28 RCTs
62 Fan 2019 Decoction To evaluate the efficacy of Gegen Qinlian Decoction for UC. n = 2028 Gegen Qinlian Decoction, Gegen Qinlian Wutan Decoction Olsalazine, Sulfasalazine, Methalazine, B. subtilis, hydrocortisone, sodium succinate 22 RCTs
63 Chi RT2019 NR To evaluate the clinical efficacy and safety of Shenqi Baizhu Powder combined with mesalazine in the treatment for UC n = 2380 Shenling Baizhu Powder Methalazine 17 RCTs
64 Tang XJ2020 NR To evaluate the clinical efficacy of Jianpi qingrehuoxue therapy for UC n = 2374 Chinese herbal medicines guided by Jianpi qingrehuoxue therapy Methalazine, SASP, live binary B. subtilis 28 RCTs
65 Liao ZW2020 Chinese patent medicine To assess the efficacy and safety of Danshen Injection in adjuvant treatment of UC n = 1102 Danshen Injection Methalazine, SASP, live binary B. subtilis 12 RCTs
66 Long TJ2020 Decoction To evaluate the efficacy of oral Chinese herbal compound on UC
with damp-heat syndrome of large intestine in RCTs
n = 378 Gegen Qinlian decoction, Yigong powder, Shaoqi chunpi decoction, Qufeng ningkui decoction, Hongteng baijiang baitouweng decoction, Baitouweng decoction Methalazine, SASP 6 RCTs
67 Long CW2021 Decoction, Chinese patent medicine To evaluate the clinical efficacy of
Sishen pill plus or reduce or combined with retention enema in the treatment of UC
n = 680 Sishen Pill Methalazine, SASP, Hydrocortisone 9 RCTs
68 Bo HJ2020 Decoction To evaluate the therapeutic effect of Wumei pill in treating UC n = 1219 Wumei Pill Methalazine, SASP 16 RCTs
69 Li PF2020 Decoction To evaluate the clinical efficacy and safety of Chinese herbal compound enema in the treatment of UC n = 1597 Baitouweng decoction, lianbei mixture, Yuyang liquid, Qinjiao Cangzhu decoction, Xileisan, Fufang Juhua granule, Changyu enema prescription, Changyu enema prescription, Qingre Zhixue decoction, Fufang Huangbai liquid, Huangqi decoction, kuijieqing, Qingre Qushi decoction, Sanhuang Decoction Methalazine, SASP 17 RCTs
70 Tan GZ2020 NR To evaluate the clinical efficacy and safety of TCM enema combined
with mesalazine in treating UC
n = 2272 NR NR 29 RCTs
71 Hu QH2021 Decoction To analyze the clinical efficacy of TCM in the treatment of
UC with damp-heated syndrome of large intestine in using Meta.
n = 695 Baitouweng decoction, Banxia Xiexin decoction, Changqingshu decoction, Changyuning granule, Gexian decoction, Jianpi Guchang decoction, Jiechang decoction, Qingchang Huashi decoction, Kuijie decoction Methalazine, SASP 9 RCTs
72 Yan ZX 2021 Decoction To assess the effcacy and safety of retention enema with TCM for UC n = 1392 Tin-like powder, Huangkui Lianchang prescription, Huangkui Lianchang prescription, Baishao Qiwu
Granules, Baitouweng and Lizhong decoctions, Hongteng decoction, Hongteng
Decoction, Hongteng decoction, Buzhong Yiqi
Decoction, Buzhong Yiqi decoction, kuijie decoction, Wubeizi powder, Kuiyangning decoction and some self-made Chinese herbal decoction
Tin-like powder, Mezalazine, SASP, 4-ASA, Gentamycin, Metronidazole sodium chloride injection, Prednisolone, Dexamethasone, 17 RCTs
73 Yuan H2020 Decoction To evaluate the efficacy and safety of Six Gentlemen Decoction intake in the treatment of UC n = 614 Six Gentlemen Decoction Methalazine, Budesonide, Spleen Yi Chang Pill 7 RCTs
  1. 1. UC Ulcerative colitis 2. SASP salazosulfapyridine 3.NR not reported 4. 5-ASA 5-aminosalicylicacid 5.DAI DNA-dependent activator of IFN-regulatory factors 6. IL innammatory factors levels of interlekin 7. ESR erythrocyte sedimentation rate 8.TNF-α tumor necrosis factor α 9.CRP C-reaction protein 10. IgA immunoglobulin A 11.IgM immunoglobulin M 12.IgG immunoglobulin G