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Table 2 Summary of the included systematic reviews

From: An evidence mapping of systematic reviews and meta-analysis on traditional Chinese medicine for ulcerative colitis

No.

Study ID (first author, year)

Interventions

Review objectives (quote from the original paper)

Population

Intervention (TCM used)

Comparator

Number of studies

1

Gong Y2014

Decoction

To evaluate the efficacy and safety of Sishen Pill in the treatment of UC.

n = 839

Sishen Pills

SASP, Gubenyichang Tablets, Bupiyichang Pill, Hydrocortisone

10 RCTs

2

Li WH2013

Decoction

To evaluate the efficacy and safety of Pulsatilla Decoction for UC.

n = 1124

Pulsatilla Decoction

SASP

10 RCTs

3

Zuo HB2013

Decoction

To evaluate the efficacy and safety of Pulsatilla Decoction for UC.

n = 1480

Pulsatilla Decoction

SASP, 5-ASA, Hormone preparation

12 RCTs

4

Pei QW2012

Decoction

To evaluate the effectiveness and safety of Jiajian Banxia Xiexin decoction forUC.

n = 736

Banxia Xiexin Decoction, Danggui Shaoyao Powder, Taohong Siwu Decoction

SASP, Bifico, Hormone preparation, Mesalazine

8 RCTs

5

Wen Y2017

Decoction, Chinese patent medicine

To make a Meta-analysis of the effectiveness and safety of Shenling Baizhu Powder for the treatment of UC, thus to provide evidence for the clinical treatment of UC.

n = 1498

Shenling Baizhu Powder

SASP, Mesalazine, Hormone preparation, Osalazine

19 RCTs

6

Chen K2016

Chinese patent medicine

Generally evaluate the therapeutic effect of Shenling Baizhu Powder combined with Western Medcine on UC.

n = 884

Shenling Baizhu Powder

SASP, Mesalazine

10 RCTs

7

Lu2017

Chinese patent medicine

To evaluate the clinical efficacy and safety of Shenling Baizhu powder in the treatment of UC by means of evidence-based medicine.

n = 1736

Shenling Baizhu Powder

Mezalazine, SASP, Metronidazole, Osalazina

20 RCTs

8

Wang XY2017

Chinese patent medicine

To evaluate the clinical efficacy and safety of Shenling Baizhu Powder in the treatment of UC.

n = 1041

Shenling Baizhu Powder

SASP, Mesalazine

12 RCTs

9

Wei Y2018

Decoction, Chinese patent medicine

To evaluate the clinical efficacy of retention enema with TCM in the treatment of UC.

n = 1447

Baishao Qiwu Granule, Changyankang I, Compound Xuejie Enema on the Blood Rheology, Colon soup, Kuijie enema, Lianbei Mixture, Qingjie Qushi Decoction, Shibai Shenbai Decoction

SASP, Hormones, gentamicin, dexamethasone, furazolidone, montmorillonite powder,smecta

16 RCTs

10

Zhang LH2018

Decoction, Chinese patent medicine

To evaluate Fuzilizhong decoction and its modified decoction systematically and summarize the clinical efficacy and safety of the treatment of UC.

n = 688

Fuzi Lizhong decoction, Sishen Pill, Kangfuxin solution

SASP, Kangfuxin

8 RCTs

11

Li HB2017

Chinese patent medicine

To systematically evaluate the clinical efficacy and safety of Compound Huangbo liquid combined with chemical medicine in the treatment of UC, and to provide evidence-based reference

n = 737

Compound Huangbo liquid, Mezalazine

SASP, Mezalazine, 5-ASA, Hormones, immunosuppressants, physiological saline

8 RCTs

12

Li HB2018

Chinese patent medicine

To systematically evaluate therapeutic efficacy and safety of Compound kushen colon-release capsule versus related chemical drugs in treatment of UC.

n = 649

Compound kushen colon-release capsule

SASP, Mezalazine, placebo

9 RCTs

13

Huang FMZ2014

Decoction

To evaluate the efficacy of JieDuXiaoYongFa and the variation of relevant indicators compared to conventional medicine for the treatment of UC.

n = 1884

NR

SASP, Mezalazine, Hormones, Gentamicin, Penicillin, Smecta

23 RCTs

14

Li HB-a2018

Chinese patent medicine

To systematically evalutate the clinical efficacy of Kangfuxin Liquid versus aminosalicylic acid in treating UC, in order to provide scientific basis for clinical promotion.

n = 806

Kangfuxin Liquid

SASP, 5-ASA, Folic acid, Metronidazole

9 RCTs

15

Liu G2011

Chinese patent medicine

To evaluate the effect of the treatment based on Kangfuxin liquid in UC.

n = 607

Kangfuxin Liquid

NR

8 RCTs

16

Gu SZ2018

Decoction, Chinese patent medicine

To systematically evaluate the efficacy and safety of the RCT of oral Chinese medicine for the treatment of UC.

n = 1703

Kuijie Decoction, Changyankang, Jianpi Yuchang Decoction, Qingchang Huashi Decoction, Sijunzi Decoction, Xianglian Zhixie Tablet, Wenjing Decoction, Juyuan Decoction, Wumei Pill, Qingre Lishi Recipe, Baiji Yukui Decoction, Changqingshu Decoction, Jianpi Huazhi Pill, Kuijiening, Zhenren Yangzang Decoction, Wenshen Jianpi Decoction, Wenyang Yuyang Decoction, Fuzheng Quxie Decoction.

SASP, Mezalazine

20 RCTs

17

Xiong AQ2011

Decoction

Objective evaluation of the treatment of UC with TCM.

n = 582

Wumei Baijiang Decoction, Shaoyao Decoction, Jianpi Decoction, Qingchang Yuyang Decoction, Qingchang Liangxue Decoction, Sijunzi Decoction, Tongxieyao Decoction, Jianpi Qushi Huazhuo Decoction.

Mezalazine

8 RCTs

18

Lv C2014

NR

To evaluate the efficacy and safety of clearing away intestinal dampness and heat methods on UC.

n = 1797

NR

SASP, Mezalazine, Metronidazole, Osalazina

20 RCTs

19

Wang DY2011

Decoction, Chinese patent medicine

To evaluate heat spleen with wet method in active treatment the curative effect of UC and security, to reveal the advantages of the method in active treatment of UC activity for TCM treatment of UC to provide the basis of evidence-based medicine.

n = 2641

Anchang Zhixie Decoction, Shenling Baizhu Decoction, Changyuning Granule, Gegen Qinlian Decoction, Kuijie Decoction, Lipi Yuyang Decoction, Baitouweng Decoction, Mankuining, Qinghua Changyin

SASP, Mezalazine, Hormones, Smecta,Metronidazole, Gentamicin, Placebo

36 RCTs

20

Liu TW2016

Decoction

To explore the effectiveness and safety of Paeoniae decoction in the treatment of UC.

n = 1181

Shaoyao Decoction

BaWei XiLei Powder, SASP, Metronidazole, berberine, hydrocortisone, oxalazine, hormones

17 RCTs

21

Yang L2017

Decoction

To evaluate the efficacy of Shaoyao Decoction in the therapy of UC.

n = 637

Shaoyao Decoction

SASP, Mezalazine

9 RCTs

22

Zhang WN2017

Decoction, Oitment

To evaluate the efficacy of Tongxie Yaofang in the therapy of UC.

n = 696

prescription for treating diarrhoea with abdominal pain, Baizhu Shaoyao Powder, Changyanling

SASP, Probiotics, Norfloxacin, Vitamin, Smecta

8 RCTs

23

Chen F2012

Decoction

To evaluate the kidney and spleen method in the treatment of remission of UC efficacy and safety.

n = 2928

Wenyang Yiqi Jiedu Decoction, Wumei Pill, Zhenpi Decoction, Huangqi Jianzhong Decoction, Bupi Yichang Decoction, Wenshen Hezhong Decoction, Fuzi Lizhong Decoction, Sishen Pill, Shenling Baizhu Powder, Buzhong Yiqi Decoction, Lizhong Decoction, Kuijieling, Xileisan, Qiwei Baizhu Powder, Jianpi Yishen Formula, Jiechang Kang, Wenbu Zhixie Decoction, Weichangning Decoction, Huangtu Decoction, Jianpi Lichang Decoction, Tiaozhong Lichang Decoction, Jiedu Shengji Decoction, Lianli Decoction and Zhenren Yangzang Decoction

SASP, Mezalazine, Xileisan, Smecta, Norfloxacin, Hormone, Gentamicin

35 RCTs

24

Yan SG2013

Decoction

To evaluate the efficacy of Wumei Pill in the therapy of UC.

n = 1170

Wumei Pill

SASP, Bupi Yichang Pill, Amoxicillin

10 RCTs

25

Xiong J2008

Decoction

To evaluate the efficacy of Wumei Pill in the therapy of UC.

n = 1159

SASP, Wumei Pill, Zhenren Yangzang Decoction, Qiwei Baizhu, Liujunzi Decoction, Sishen Pill

SASP, Hormone

10 RCTs

26

Chen MY2018

Chinese patent medicine

To systematically evaluate the clinical efficacy and safety of Xilei Powder compared with mesalamine in the treatment of UC.

n = 373

Xilei Powder

Mezalazine

6 RCTs

27

Chen MY2018-a

Chinese patent medicine

Meta-analysis of Xileisan combined with Mesalazine in the treatment of UC.

n = 840

Xilei Powder

SASP, Hormone

12 RCTs

28

Cui DJ2012

Chinese patent medicine

To evaluate the efficacy and safety of Xilei powder on UC.

n = 83

Xilei Powder

Mezalazine

2 RCTs

29

Ma XM2012

Chinese patent medicine

To systematically evaluate the clinical efficacy of Xileisan in the treatment of UC.

n = 1476

Xilei Powder

SASP, 5-ASA, Smecta, Hormone, Antibiotic

21 RCTs

30

Lai YL2013

Decoction

To evaluate the clinical efficacy of TCM with Xinkai Kujiang method in the treatment of UC.

n = 551

Wumei Pill, Lianli Wumei Decoction, Chaigui Ganjiang Decoction

SASP, Mezalazine

9 RCTs

31

Zhu JB2016

Decoction

To make a systematic review on the clinical effect and safety of modifiedBanxia Xiexin Decoction in the treatment of UC.

n = 1200

Banxia Xiexin Decoction

NR

14 RCTs

32

Huang ZB2014

Chinese patent medicine

To systematically evaluate the effectiveness of Yunnan Baiyao in treating UC.

n = 1463

Yunnan white Drug

SASP, 5-ASA

20 RCTs

33

Qi J2016

Decoction

To evaluate the clinical efficacy of Zhenren Yangzang Decoction in the treatment of UC.

n = 209

Zhenren Yangzang Decoction

SASP

3 RCTs

34

luo Y2012

NR

Evaluation the efficicy and safety about the Chinese and Western method of treatment on UC.

n = 7740

NR

NR

113 RCTs

35

Xu P2015

Decoction, Chinese patent medicine

1 To sum up the results of the RCT about the treatments of UC with integrative medicine.2 Using Mete-analysis methods to evaluate the effectiveness,safety and the rates of recurrence,in order to provide reference and guidance for clinical treatment of UC.

n = 1696

Pulsatilla Decoction, Kangfuxin Liquid, Hongteng Decoction, Puqin Baijiang Decoction

conventional medicine

20 RCTs

36

Gong YD2012

NR

Evaluate wether conventional medicine combined TCM therapy more advantageous than simple Western medicine therapy.

n = 1897

NR

conventional medicine

16 RCTs

37

Ma DZ2015

NR

Comprehensive evaluation of the clinical efficacy of retention enema with TCM in the adjuvant treatment of UC.

n = 1358

NR

conventional medicine

18 RCTs

38

Huang SG2010

Decoction, Chinese patent medicine

Applying the method of Meta-Analysis, generally evaluation the therapeutic effect of retention-enema of Chinese herb treating UC.

n = 875

Danshen enema, Hongteng mixture, Kuju solution, Kuijieqing enema, Huangqi Decoction, Baitouweng Decoction

SASP, Hormone, Antibiotic, Sulfamethoxazole

7 RCTs

39

Ni XX2019

Decoction, Chinese patent medicine

To systematically evaluate the efficacy and safety of retention enema with Chinese materia in the treatment of UC.

n = 3110

Yunnan white Drug, Xilei Powder, Qibei Mixture, Zhikang Capsule, Shenling Baizhu Powder

conventional medicine

36 RCTs

40

Jiang T2006

NR

To assess the theraoeutic effectiveness of retention enema with TCM in the treatment of UC.

n = 2092

NR

SASP, Hormone, Antibiotic

23 RCTs

41

Zhu XG2012

Decoction, Chinese patent medicine

Comprehensive evaluation of clinical efficacy of retention enema with TCM in the treatment of UC.

n = 1584

Yunnan White Drug, Jiechang Decoction, Kuijiekang, Kuju Liquid, Yuchang Zhengchang Decoction, Tongguan Decoction, Yasanzi Sanhuang Decoction, Hongteng Mixture, Yuyang Anchang Decoction, Danshen enema Liquid, Xilei Liquid, Kuijieqing enema Liquid, Pulsatilla Decoction, Huangqi Decoction.

SASP, Hormone, Antibiotic, Smecta, Sulfamethoxazole compound

15 RCTs

42

You WF2017

NR

Quantitative analysis of clinical efficacy of retention enema of TCM for UC based on evidence-based medicine methodology.

n = 988

NR

NR

7 RCTs

43

Cui DJ-a2012

Chinese patent medicine

To evaluate the efficacy and safety of Bupi Yichang Pill in the therapy of UC.

n = 596

Bupi Yichang Pill

SASP, Mezalazine, balsalazide

6 RCTs

44

WuZl2017

Decoction, Chinese patent medicine

To evaluate the therapeutic effect of TCM enema combined with mesalazine in treating UC.

n = 1521

Changkui Decoction, Qingchang Huashi Decoction, Qingchang Yuyang Decoction, Shenling Baizhu Powder and Baitouweng Decoction

Mezalazine

22 RCTs

45

Huang HJ2012

NR

The objective of this study was to systematicly ewduate the clinical therapeutic effcct of Chinese materia medica and western drugs used in retention enema for treating UC.

n = 476

NR

NR

5 RCTs

46

Zha AS2015

NR

The aim of this study was to evaluate the safety and efficacy of Huoxue Huayumethod of TCM in the treatment of UC.

n = 1897

NR

Mezalazine, SASP, Hormones, Antibiotics, Metronidazole

20 RCTs

47

Hou LW2017

Decoction

To review systematically the therapeutic effects and safety on UC treated with the oral administration and enema with TCM

n = 1507

Tiaoqi Jiedu Decoction, Yuchang Decoction, Shenling Baizhu Powder, Gegen Qinlian Decoction, Shaoyao Decoction, Changyan Decoction, Jianpi Lichang Decoction, Self-made Xiaoulcer, Gegen Qinlian Wutan Decoction

SASP, Hormones, Ampicillin

18 RCTs

48

Hou LW2015

Decoction, Chinese patent medicine

To systematically evaluate clinical efficacy of oral medicine decoction with enema treatment of UC.

n = 856

Colon Ning Mixture, Yuyangning Decoction, Tongxie Yaofang, Shenling Baizhu Powder, Shaoyao Decoction, Gegen Qinlian Decoction, Gegen Qinlian Wutan Decoction

SASP, Hormones, Antibiotic

11 RCTs

49

Gan YK2015

Decoction

To evaluate the efficacy of TCM for oral compared with Mesalazine in thetreatment of UC through meta-analysis.

n = 543

Changqingshu Decoction, Sijunzi Decoction and Tongxie Decoction, Qingchang Yuyang Decoction, Wumei Baicai Decoction, Jianpi Decoction, Qingchang Liangxue Decoction, Jianpi Qushihuo Decoction

Mezalazine

7 RCTs

50

Zhu JM2011

NR

To evaluate the clinical efficacy of Chinese medicine treatment on UC.

n = 2702

NR

SASP, Basalazide, Mesalazine, Smecta, Antibiotics, Hormones, Vitamins

33 RCTs

51

Wang DY2013

Decoction, Chinese patent medicine

To evaluate the curative effect and safety of TCM Heat-Clearing and Damp-Excreting and Spleen-Strengthening Method for the treatment of active UC.

n = 896

Modified Yuyang Decoction, Huangqi Jianzhong Decoction, Huoxue Lichang Decoction, Jianpi Lishi Decoction, Kuijieling No. 1, Qibaiyichang Decoction, Qini Yuyang Decoction, Baitouweng Decoction, Kuijiefukang Decoction, Qingre Lishi Yichang Decoction, Baitouweng Decoction, Liuhe Decoction, Jianpiyukui Decoction, Chinese Herbal Enema Prescription

SASP, Smecta, Hormone, Ciprofloxacin

13 RCTs

52

Wang Y2018

NR

To evaluate the regulation of gut flora in patients with UC on TCM.

n = 392

NR

SASP, Mezalazine

5 RCTs

53

He M2007

NR

Comparing the clinical efficacy of TCM preparation and SASP in the treatment of UC.

n = 611

NR

SASP

7 RCTs

54

Pei QW2013

Decoction, Chinese patent medicine

To evaluate the effectiveness and safety of method of chinese herbs oral therapy for treating UC.

n = 1923

Tongxiening Granule, Fuling Powder, Wumei Pill, Mahuang Fuzi Xixin Decoction, Compound Kushen Colon-dissolving Capsule, Xuefu Zhuyu Decoction, Shaoyao Decoction, Kuijie Recurrent Decoction, Ulcer Powder, Zhuche Pill, Guipi Decoction, Changpikang, Qixian Anchang Decoction, Jianpi Zaoshi Decoction, Kuijietong Decoction, QinGeng Chunpi Decoction Liquor, Coix Root and Fructus Aconiti Patriniae Powder, Changyankang Oral Liquid, Warming Spleen Decoction, Banxia Xiexin Decoction, Danggui Shaoyao Powder, Taohong Siwu Decoction, Qiwei Baizhu Powder

SASP, Hormones, Oxalazine, Folic acid, miya, Mesalazine

23 RCTs

55

Yang AX2006

NR

To compare clinical therapeutic effects of simple TCM and simple conventional medicines on UC.

n = 1237

NR

NR

11 RCTs

56

Zhu L2012

NR

To compare clinical therapeutic effects of simple TCM and 5-ASA on UC.

n = 739

NR

NR

11 RCTs

57

Jia JW2019

Decoction, Chinese patent medicine

Systematic evaluation of the clinical efficacy of TCM retention enema in the treatment of UC.

n = 1450

Colon Qingfang, Kuijie Enema Decoction, Qingre Jiedu Decoction, Ulcer Powder, Sanqi Zicao Decoction, Diyu Charcoal with Baiji, Sanhuang Decoction, Kuijie Decoction, Baishao Licorice Decoction

SASP, Metronidazole, Dexamethasone, Hydrocortisone, Mesalazine, Gentamicin, Tinidazole, Gentamicin sulfate, Oxalazine

16 RCTs

58

Li L2019

Decoction

Systematic evaluation of the efficacy and safety of TCM for clearing away heat and dampness combined with conventional medicine in the treatment of UC.

n = 1176

Bai Tou Weng Decoction, Qingluo Huachang Decoction, Gegen Qinlian Decoction, Yiqi Qingchang Decoction, Baitouweng plus Gancao and Ejiao Decoction, Shaoyao Decoction, Qingchang Powder, Qingchi Powder, Qingre Changyu Decoction, Yu Chang Ning capsule, Kuiyu Decoction

SASP, Mezalazine

15 RCTs

59

Chen MJ2019

Decoction, Chinese patent medicine

To systematically evaluate clinical effects of proprietary Chinese medicine containing

Sophora Flavescens on UC.

n = 883

Composite Sophora Colon-soluble Capsules, Kuh-seng Injection, Kuh-seng enema, Tongguan liquid, Baihe and Kuh-seng enema, Kuh-seng Huaihua mixture

SASP, Mezalazine

9 RCTs

60

Wu N2019

Decoction

Systematic evaluation of the efficacy and safety of Huangqin Decoction in UC.

n = 777

Huangqin Decoction

SASP, Mezalazine, Probiotics

10 RCTs

61

Peng JF2019

Decoction, Chinese patent medicine

To evaluate the therapeutic effect of TCM retention enema in treating UC.

n = 2477

Colon An Liquid, Yuanxing Changan Liquid, Shengji Powder, Xihuang Mixture, Kuijie Powder, Huanglian Decoction, Xilei Powder, Kangfuxin Liquid, Pearl Guchang Powder, Jiaodai Decoction

SASP, Mesalazine

28 RCTs

62

Fan 2019

Decoction

To evaluate the efficacy of Gegen Qinlian Decoction for UC.

n = 2028

Gegen Qinlian Decoction, Gegen Qinlian Wutan Decoction

Olsalazine, Sulfasalazine, Methalazine, B. subtilis, hydrocortisone, sodium succinate

22 RCTs

63

Chi RT2019

NR

To evaluate the clinical efficacy and safety of Shenqi Baizhu Powder combined with mesalazine in the treatment for UC

n = 2380

Shenling Baizhu Powder

Methalazine

17 RCTs

64

Tang XJ2020

NR

To evaluate the clinical efficacy of Jianpi qingrehuoxue therapy for UC

n = 2374

Chinese herbal medicines guided by Jianpi qingrehuoxue therapy

Methalazine, SASP, live binary B. subtilis

28 RCTs

65

Liao ZW2020

Chinese patent medicine

To assess the efficacy and safety of Danshen Injection in adjuvant treatment of UC

n = 1102

Danshen Injection

Methalazine, SASP, live binary B. subtilis

12 RCTs

66

Long TJ2020

Decoction

To evaluate the efficacy of oral Chinese herbal compound on UC

with damp-heat syndrome of large intestine in RCTs

n = 378

Gegen Qinlian decoction, Yigong powder, Shaoqi chunpi decoction, Qufeng ningkui decoction, Hongteng baijiang baitouweng decoction, Baitouweng decoction

Methalazine, SASP

6 RCTs

67

Long CW2021

Decoction, Chinese patent medicine

To evaluate the clinical efficacy of

Sishen pill plus or reduce or combined with retention enema in the treatment of UC

n = 680

Sishen Pill

Methalazine, SASP, Hydrocortisone

9 RCTs

68

Bo HJ2020

Decoction

To evaluate the therapeutic effect of Wumei pill in treating UC

n = 1219

Wumei Pill

Methalazine, SASP

16 RCTs

69

Li PF2020

Decoction

To evaluate the clinical efficacy and safety of Chinese herbal compound enema in the treatment of UC

n = 1597

Baitouweng decoction, lianbei mixture, Yuyang liquid, Qinjiao Cangzhu decoction, Xileisan, Fufang Juhua granule, Changyu enema prescription, Changyu enema prescription, Qingre Zhixue decoction, Fufang Huangbai liquid, Huangqi decoction, kuijieqing, Qingre Qushi decoction, Sanhuang Decoction

Methalazine, SASP

17 RCTs

70

Tan GZ2020

NR

To evaluate the clinical efficacy and safety of TCM enema combined

with mesalazine in treating UC

n = 2272

NR

NR

29 RCTs

71

Hu QH2021

Decoction

To analyze the clinical efficacy of TCM in the treatment of

UC with damp-heated syndrome of large intestine in using Meta.

n = 695

Baitouweng decoction, Banxia Xiexin decoction, Changqingshu decoction, Changyuning granule, Gexian decoction, Jianpi Guchang decoction, Jiechang decoction, Qingchang Huashi decoction, Kuijie decoction

Methalazine, SASP

9 RCTs

72

Yan ZX 2021

Decoction

To assess the effcacy and safety of retention enema with TCM for UC

n = 1392

Tin-like powder, Huangkui Lianchang prescription, Huangkui Lianchang prescription, Baishao Qiwu

Granules, Baitouweng and Lizhong decoctions, Hongteng decoction, Hongteng

Decoction, Hongteng decoction, Buzhong Yiqi

Decoction, Buzhong Yiqi decoction, kuijie decoction, Wubeizi powder, Kuiyangning decoction and some self-made Chinese herbal decoction

Tin-like powder, Mezalazine, SASP, 4-ASA, Gentamycin, Metronidazole sodium chloride injection, Prednisolone, Dexamethasone,

17 RCTs

73

Yuan H2020

Decoction

To evaluate the efficacy and safety of Six Gentlemen Decoction intake in the treatment of UC

n = 614

Six Gentlemen Decoction

Methalazine, Budesonide, Spleen Yi Chang Pill

7 RCTs

  1. 1. UC Ulcerative colitis 2. SASP salazosulfapyridine 3.NR not reported 4. 5-ASA 5-aminosalicylicacid 5.DAI DNA-dependent activator of IFN-regulatory factors 6. IL innammatory factors levels of interlekin 7. ESR erythrocyte sedimentation rate 8.TNF-α tumor necrosis factor α 9.CRP C-reaction protein 10. IgA immunoglobulin A 11.IgM immunoglobulin M 12.IgG immunoglobulin G