Table 2 Potential anti-OA effects of LBP

Authors

Year

Model

Dosage of LBP

Measured approach

Key findings

Limitations

Ni H, et al. [54]

2019

IL-1β evoked inflammatory injury in ATDC5 cell

300lg/mL LBP

The expression of TNF-α, IL-6, IL-8, Cox-2 and miR-124

LBP could decrease the expression of TNF-α, IL-6 and IL-8, and inhibit the expression of Cox-2, which evoked by IL-1β. LBP could increase the concentration of miR-124, then inhibited the activation of JNK and NF-κB pathways.

Jing L, et al. [55]

2018

Palmitate-induced apoptosis in MC3T3-E1 osteoblasts cells

0, 50, 100, 200, 400 and 800 μg/ml

Cell viability, apoptotic rate and the expression of apoptosis-related genes.

LBP could inhibit palmitate-induced apoptosis which is in a dose-dependent manner, and the activation of the JNK pathway. LBP could decrease the expression of Caspase-3, Caspase-9, Caspase-12, GRP78 and CHOP.

Cai ST, et al. [56]

2018

Human OA chondrocytes

0, 100, 200, 400 and 800 μg/mL

Expression of inflammatory cytokines of OA chondrocytes

LBP could inhibit the proliferation of OA chondrocytes in a concentration-dependent manner. 400 μg/mL LBP significantly reduced the levels of IL-1 β, TNF-α, iNOS and NF-κBp65 in the supernatant of OA chondrocytes and increased TGF-β expression. LBP could inhibit NF- κ B signal pathway and the inflammatory response of OA chondrocytes cultured in vitro.

Authors

Year

Animal model

Dosage of LBP

Treatment approach

Key findings

Limitations

Liu Y, et al. [57]

2015

collagen type II-induced arthritis mouse model

25, 50 and 100 mg/kg

Intraperitoneal injection for continuous10 days, once daily.

The expression of TNF-α, IL-6, IL-17, MMP-1 and MMP-3. To observe the bone morphology and measure the paw diameter.

LBP could reduce the paw thickness, protect the bone integrity, and decrease the expression of TNF-α, IL-6 and IL-17, which are all in a dose-dependent manner. LBP could reduce the expression of MMP-1 and MMP-3 but not in a dose-dependent manner.