Anti-allergic activities of Umbelliferone against histamine- and Picryl chloride-induced ear edema by targeting Nrf2/iNOS signaling in mice

Table 1 Hematological parameters of allergic ear edema induced by PiCl+Toluene topical application

Hematological Parameters	Normal control (mean ± SEM)	Picryl chloride (mean ± SEM)	Dexa (10 mg/kg) (mean ± SEM)	UMB (1 mg/kg) (mean ± SEM)	UMB (10 mg/kg) (mean ± SEM)	UMB (50 mg/kg) (mean ± SEM)
Eosinophil’s (%)	0.62 ± 0.23	6.7 ± 0.08^###	4.3 ± 0.16	5.70 ± 0.34	5.1 ± 0.38^**	4.7 ± 0.32^***
Basophils (%)	0.3 ± 0.44	0.6 ± 0.034^###	0.32 ± 0.13	0.5 ± 0.42	0.43 ± 0.51^**	0.33 ± 0.40^***
Neutrophils (%)	23.5 ± 1.53	53 ± 0.13^###	31 ± 0.36	39 ± 0.28	37 ± 0.45^**	34 ± 0.45^***
Monocytes (%)	3.5 ± 0.07	5.3 ± 0.11^###	4.9 ± 0.43	5.1 ± 0.47	4.7 ± 0.21^**	4.8 ± 0.20^***
WBC (×10³/mm³)	2.7 ± 0.29	3.5 ± 0.50^###	2.7 ± 021	2.6 ± 0.61	2.8 ± 0.41^**	2.9 ± 0.65^***

The data were represented as mean ± standard deviation (n = 5). (*) p<0.05, (**) p<0.01, (***) p<0.001 indicates significance, while ### shows comparison with the negative control

ISSN: 2662-7671