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Table 3 Summary of finding table of resveratrol compared to placebo for bone mineral density

From: Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials

Resveratrol compared to Placebo for bone mineral density in human

Patient or population: Adults

Setting:

Intervention: Resveratrol

Comparison: Placebo

Outcome

№ of participants

(studies)

Anticipated absolute effects (95% CI)

Certainty

Without resveratrol

With resveratrol

Difference

BMD at lumbar spine

assessed with: dual-energy X-ray absorptiometryfollow up: range 16 weeks to 12 months

№ of participants: 370 (3 RCTs)

The mean BMD at lumbar spine was 1.04–1.073

–

MD 0.02 lower (0.05 lower to 0.01 higher)

⨁◯◯◯

VERY LOW a,b,c

Serum PINP follow up: range 4 weeks to 16 weeks

№ of participants: 90 (2 RCTs)

The mean serum PINP ranged from 8.6–41.3

–

MD 2.92 lower (6.33 lower to 0.5 higher)

⨁◯◯◯

VERY LOW a,b,d

  1. *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI)
  2. CI: Confidence interval; MD: Mean difference
  3. GRADE Working Group grades of evidence
  4. High certainty: We are very confident that the true effect lies close to that of the estimate of the effectModerate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
  5. Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effectVery low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect
  6. Explanations
  7. a. There were some high risk of bias of included trials according to the risk of bias assessment
  8. b. There were some incomplete outcome data among the included studies and some data were imputed for the analysis
  9. c. There were only three studies showing positive or no effect, it seems that studies showing negative effect have not been published
  10. d. Results were based on two studies with a small sample size and wide 95% confidence interval
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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