Fig. 5From: Bupi Yishen formula attenuates kidney injury in 5/6 nephrectomized rats via the tryptophan-kynurenic acid-aryl hydrocarbon receptor pathwayTryptophan-KA-AhR pathway. BYF increased the production of kynurenic acid and melatonin, whereas it decreased the production of indole-3-acetic acid. The intensities of tryptophan (A), kynurenic acid (B), indole-3-acetic acid (C), and melatonin (D) were measured by LC-MS/MS. (E-F) BYF inhibited the expression of the AhR signaling pathway. n = 3 per group (*P < 0.05, **P < 0.001)Back to article page