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Table 1 IC50 (μM) values were determined via the MTT assaya

From: Piperlongumine inhibits migration and proliferation of castration-resistant prostate cancer cells via triggering persistent DNA damage

Cell lines / compound

IC50 (μM)

PC3

DU145

WPMY-1

LO2

PL

6.75 ± 0.75

8.42 ± 0.98

8.73 ± 0.32

68.62 ± 5.38

Taxol

7.88 ± 0.89

7.26 ± 0.69

4.37 ± 0.18

34.70 ± 1.03

DDP

27.81 ± 4.53

8.83 ± 1.25

7.43 ± 0.85

11.58 ± 0.35

Dox

33.19 ± 1.68

41.50 ± 1.15

2.14 ± 0.15

80.61 ± 3.89

5-FU

96.33 ± 1.86

25.75 ± 2.53

97.24 ± 2.03

94.97 ± 4.84

  1. aIC50 values were drug concentrations necessary for 50% inhibition of cell viability. Data are average ± standard deviations of at least three independent experiments. The drug treatment period was 48 h