Fig. 1

PL inhibits the migration of CRPC cells. A and B, PL decreases cell adhesion to the extracellular matrix in PC3 and DU145 cells. C and E, PL inhibits PC3 and DU145 cell migration in scratch-wound healing assays. The different time periods of PC3 and DU145 were adopted in scratch wound assay due to the difference migration speed between PC3 and DU145. Scale bar, 100 μm. D and F, Quantification of (C) and (E). G and H, PL inhibits PC3 and DU145 migration in transwell assays. Values represent the mean ± standard deviation (SD) of at least three independent experiments. Statistical significance was calculated using unpaired Student’s two-tailed t tests for A, B, G, H, and two-way analysis of variance (ANOVA) for D and F with the p-values (*p < 0.05, **p < 0.01, ***p < 0.001)