Fig. 2

Effect of SHA on ankle swelling and clinical score of MSU-induced acute gouty arthritis in mice. A Representative photos of MSU-induced mouse ankle joint swelling captured at 24 h postinjection. Images at the lower panel are magnified pictures of the region indicated by the white arrows in the upper image. B & C, N.S., control saline group; MSU, MSU crystal-injected mice; COL-0.5, mice treated with MSU and 0.5 mg/kg colchicine; SHA-10, mice treated with MSU and 10 mg/kg SHA; SHA-20, mice treated with MSU and 20 mg/kg SHA. B MSU crystal-induced mouse ankle swelling at different times. C The clinical score evaluation for all mice after the ankle swelling measurement. All values are presented as the mean ± SD (n = 10). ^## P < 0.01 versus the saline group; * P < 0.05, ** P < 0.01 versus the MSU group