Phytochemical, acute toxicity and renal protective appraisal of Ajuga parviflora hydromethanolic leaf extract against CCl4 induced renal injury in rats

Table 7 Effect of APHM on the biomolecules of renal tissues after CCl₄ induced renal injury in rats

Treatment Groups	Doses (mg/kg)	GSH^c μM/g tissue	TBARS^d(nM/min/mg protein)	H₂O₂ μM/min	Nitrite μM/min
Naïve	–	30.57 ± 2.20^b	3.18 ± 0.62^b	1.22 ± 0.17^b	108.45 ± 3.15^b
Control	–	16.35 ± 2.22	5.88 ± 0.45	2.85 ± 0.26	145.35 ± 2.20
APHM^e	100	24.65 ± 1.45^a	4.04 ± 0.20^a	2.15 ± 0.21^a	119.25 ± 4.55^a
APHM	200	29.33 ± 1.15^b	3.11 ± 0.25^b	1.28 ± 0.22^b	108.25 ± 2.15^b
APHM	300	32.65 ± 1.22^b	2.85 ± 0.21^b	1.35 ± 0.13^b	102.22 ± 2.25^b
Silymarin	100	18.10 ± 1.75^b	4.11 ± 0.15^a	1.55 ± 0.20^b	110.54 ± 2.10^b

Naïve groups did not received any treatment while control received CCl₄ only
n = 6, Average values ± SEM,
^ap ≤ 0.05 significant as compared to control, ^bp ≤ 0.005 highly significant as compared to control
^cReduced glutathione, ^dThiobarbituric acid reactive substance, ^eAjuga parviflora hydromethanolic extract

ISSN: 2662-7671