Phytochemical, acute toxicity and renal protective appraisal of Ajuga parviflora hydromethanolic leaf extract against CCl4 induced renal injury in rats

Table 6 Effect of APHM on phase I and phase II antioxidant enzymes in renal tissue after CCl₄ induced renal injury in rats

Treatment groups	Doses (mg/kg)	Phase I antioxidant enzymes			Phase II antioxidant enzymes
Treatment groups	Doses (mg/kg)	Catalase U/min	POD^c U/min	SOD^d U/min	GST^e (nM/min/mg protein)	GSR^f(μg/mg protein)
Naïve	–	5.75 ± 0.28^b	6.72 ± 0.36^b	5.65 ± 0.22^b	22.62 ± 1.21^b	138.44 ± 3.45^b
Control	–	2.32 ± 0.21	3.10 ± 0.23	1.85 ± 0.16	10.58 ± 0.35	71.25 ± 2.57
APHM^g	100	3.25 ± 0.25	4.65 ± 0.35	3.12 ± 0.15^a	20.25 ± 1.00^b	109.20 ± 2.17^a
APHM	200	4.50 ± 0.22^a	5.95 ± 0.23^a	4.95 ± 0.44^b	21.11 ± 1.10^b	127.25 ± 2.55^b
APHM	300	5.78 ± 0.41^b	6.68 ± 0.1b^a	5.56 ± 0.52^b	21.82 ± 1.16^b	139.12 ± 1.82^b
Silymarin	100	5.65 ± 0.11^b	5.70 ± 0.45^b	5.22 ± 0.33^b	21.45 ± 1.15^b	131.21 ± 2.65^b

Naïve groups did not received any treatment while control received CCl₄ only
n = 6, Average values ± SEM,
^ap ≤ 0.05 significant as compared to control, ^bp ≤ 0.005 highly significant as compared to control
^cPeroxidase, ^dSuperoxide dismutase, ^eGlutathione-S-transferase, ^fGlutathione reductase, ^gAjuga parviflora hydromethanolic extract

ISSN: 2662-7671