Table 6 Effects of crude extract, fractions and subfractions of I. dipyrena on hot plate and involvement of opioid system
From: Evaluation of antinociceptive activity of Ilex dipyrena Wall. in mice
Treatment | Doses | 0 min | 30 min | 60 min | 90 min | 120 min | At 60 min |
|---|---|---|---|---|---|---|---|
Control | – | 3.19 ± 1.57 | 3.07 ± 2.01 | 3.15 ± 1.12 | 3.09 ± 1.21 | 3.11 ± 2.14 | – |
Crd-Id | 100 | 3.29 ± 2.15 | 5.31 ± 1.11 | 7.79 ± 1.10*** | 7.11 ± 1.91 | 6.69 ± 1.74 | 57.15% |
Crd-Id | 200 | 3.40 ± 1.51 | 5.77 ± 1.46 | 8.54 ± 1.10*** | 8.02 ± 1.91 | 7.21 ± 2.31 | 63.11% |
Chl- Id | 75 | 3.12 ± 2.31 | 6.31 ± 1.91 | 9.61 ± 2.31** | 9.13 ± 1.51 | 8.11 ± 1.46 | 67.22% |
Et- Id | 75 | 3.21 ± 1.63 | 6.41 ± 1.47 | 8.07 ± 1.62*** | 9.72 ± 1.35 | 8.19 ± 2.71 | 60.96% |
Fr.Chl-Id 46 | 75 | 3.61 ± 1.73 | 6.32 ± 1.71 | 8.19 ± 1.38*** | 9.18 ± 1.53 | 8.27 ± 2.11 | 61.53% |
Fr.Chl-Id 47 | 75 | 3.28 ± 2.05 | 5.49 ± 1.91 | 8.87 ± 1.09*** | 7.59 ± 1.56 | 6.58 ± 1.47 | 64.48% |
Fr.Chl-Id 48 | 75 | 3.13 ± 2.11 | 6.27 ± 1.31 | 9.87 ± 1.47** | 10.21 ± 2.17 | 9.34 ± 1.49 | 68.08% |
Tramadol | 20 | 3.01 ± 1.18 | 7.71 ± 1.21 | 17.01 ± 1.91*** | 12.19 ± 1.37 | 11.21 ± 1.67 | 81.48% |
Crd- Id +Naloxone | 100 + 2 | 3.09 ± 1.14 | 3.07 ± 1.59 | 3.32 ± 2.12 | 3.29 ± 1.91 | 3.01 ± 1.91 | – |
Crd- Id +Naloxone | 200 + 2 | 3.02 ± 1.41 | 3.11 ± 1.91 | 3.22 ± 1.67 | 3.31 ± 1.83 | 3.12 ± 1.67 | – |
Chl- Id +Naloxone | 75 + 2 | 3.01 ± 2.21 | 3.16 ± 1.16 | 3.41 ± 1.87 | 3.11 ± 2.31 | 3.12 ± 1.29 | – |
Et- Id +Naloxone | 75 + 2 | 3.03 ± 1.51 | 3.42 ± 1.13 | 3.11 ± 1.28 | 3.57 ± 1.72 | 3.16 ± 2.01 | – |
Fr.Chl-Id 46 + Naloxone | 75 + 2 | 3.11 ± 1.22 | 3.33 ± 1.87 | 3.37 ± 1.76 | 3.41 ± 1.24 | 3.30 ± 1.19 | – |
Fr.Chl-Id 47 + Naloxone | 75 + 2 | 3.38 ± 1.67 | 3.52 ± 1.91 | 3.56 ± 1.31 | 3.31 ± 1.71 | 3.49 ± 1.87 |  |
Fr.Chl-Id 48 + Naloxone | 75 + 2 | 3.37 ± 1.91 | 3.18 ± 1.28 | 3.21 ± 1.93 | 3.42 ± 1.37 | 3.11 ± 2.03 | – |
Tramadol+Naloxone | 20 + 2 | 3.21 ± 1.31 | 3.17 ± 2.11 | 3.41 ± 1.61 | 3.29 ± 1.92 | 3.17 ± 1.16 | – |