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Table 5 Effects of the crude extract, fractions, and subfractions of I. dipyrena on tail immersion analgesic response

From: Evaluation of antinociceptive activity of Ilex dipyrena Wall. in mice

Treatment

Dose

Pre Treatment

Post Treatment

% inhibition

Control (2% Tween 80)

–

3.97 ± 2.09

4.09 ± 1.21

–

Crd-Id

100

3.81 ± 2.09

8.89 ± 1.73***

57.15

Crd-Id

200

3.74

9.43 ± 1.03***

60.35

Chl-Id

75

3.82 ± 1.81

10.25 ± 1.49**

62.72

Et-Id

75

3.92 ± 1.67

9.49 ± 1.82**

58.71

Fr. Chl-Id 46

75

4.01 ± 1.39

10.06 ± 1.37**

60.16

Fr. Chl-Id 47

75

3.94 ± 1.67

10.68 ± 1.52**

63.12

Fr. Chl-Id 48

75

3.75 ± 1.92

11.50 ± 1.19***

67.39

Tramadol

20 mg

3.81 ± 1.81

15.86 ± 1.17***

75.98

  1. Each value is represented as Mean ± SEM (n = 8). Where, *P < 0.05, **P < 0.01 and ***P < 0.001 statistically significant relative to control. Crd-Id Crude extract, Hex-Id n-hexane fraction, Chl-Id chloroform fraction, Et-Id Ethyl acetate fraction, Fr.Chl-Id 46, 47 and 48 subfractions