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Table 5 100 Highest-Cited Publications in TCAIM Journals

From: Insight into the characteristics of research published in traditional, complementary, alternative, and integrative medicine journals: a bibliometric analysis

Position

Title

Authors

Year

Source Title

Citation Count

1

Natural products as sources of new drugs over the last 25 years

Newman D.J., Cragg G.M.

2007

Journal of Natural Products

3258

2

Flavonoids as antioxidants

Pietta P.-G.

2000

Journal of Natural Products

3162

3

Natural products as sources of new drugs over the 30 years from 1981 to 2010

Newman D.J., Cragg G.M.

2012

Journal of Natural Products

3122

4

Brine shrimp: A convenient general bioassay for active plant constituents

Meyer B.N., Ferrigni N.R., Putnam J.E., Jacobsen L.B., Nichols D.E., McLaughlin J.L.

1982

Planta Medica

2939

5

Natural products as sources of new drugs from 1981 to 2014

Newman D.J., Cragg G.M.

2016

Journal of Natural Products

2750

6

Natural products as sources of new drugs over the period 1981–2002

Newman D.J., Cragg G.M., Snader K.M.

2003

Journal of Natural Products

2285

7

Free radicals, antioxidants and functional foods: Impact on human health

Lobo V., Patil A., Phatak A., Chandra N.

2010

Pharmacognosy Reviews

1939

8

Pharmacology of Curcuma longa

Ammon H.P.T., Wahl M.A.

1991

Planta Medica

1415

9

A sensitive and quick microplate method to determine the minimal inhibitory concentration of plant extracts for bacteria

Eloff J.N.

1998

Planta Medica

1320

10

Screening of plant extracts for antioxidant activity: A comparative study on three testing methods

Koleva I.I., Van Beek T.A., Linssen J.P.H., De Groot A., Evstatieva L.N.

2002

Phytochemical Analysis

1186

11

Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers

Shoba G., Joy D., Joseph T., Majeed M., Rajendran R., Srinivas P.S.S.R.

1998

Planta Medica

1178

12

Natural products in drug discovery and development

Cragg G.M., Newman D.J., Snader K.M.

1997

Journal of Natural Products

1126

13

Natural polyphenols (vegetable tannins) as drugs: Possible modes of action

Haslam E.

1996

Journal of Natural Products

960

14

Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement (Chinese edition)

Moher D., Liberati A., Tetzlaff J., Altman D.G., Altman D., Antes G., Atkins D., Barbour V., Barrowman N., Berlin J.A., Clark J., Clarke M., Cook D., D’Amico R., Deeks J.J., Devereaux P.J., Dickersin K., Egger M., Ernst E., Gøtzsche P.C., Grimshaw J., Guyatt G., Higgins J., Ioannidis J.P.A., Kleijnen J., Lang T., Magrini N., McNamee D., Moja L., Mulrow C., Napoli M., Oxman A., Pham B., Rennie D., Sampson M., Schulz K.F., Shekelle P.G., Tovey D., Tugwell P.

2009

Journal of Chinese Integrative Medicine

933

15

The role of natural product chemistry in drug discovery

Butler M.S.

2004

Journal of Natural Products

918

16

Natural products from endophytic microorganisms

Strobel G., Daisy B., Castillo U., Harper J.

2004

Journal of Natural Products

916

17

Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research

Jurenka J.S.

2009

Alternative Medicine Review

837

18

Dose escalation of a curcuminoid formulation

Lao C.D., Ruffin IV M.T., Normolle D., Heath D.D., Murray S.I., Bailey J.M., Boggs M.E., Crowell J., Rock C.L., Brenner D.E.

2006

BMC Complementary and Alternative Medicine

833

19

Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers

Cos P., Ying L., Calomme M., Hu J.P., Cimanga K., Van Poel B., Pieters L., Vlietinck A.J., Vanden Berghe D.

1998

Journal of Natural Products

823

20

Mindfulness-based stress reduction for stress management in healthy people: A review and meta-analysis

Chiesa A., Serretti A.

2009

Journal of Alternative and Complementary Medicine

789

21

Th1/Th2 balance: The hypothesis, its limitations, and implications for health and disease

Kidd P.

2003

Alternative Medicine Review

781

22

Annonaceous acetogenins: Recent progress

Alali F.Q., Liu X.-X., McLaughlin J.L.

1999

Journal of Natural Products

745

23

Antidiabetic plants and their active constituents

Marles R.J., Farnsworth N.R.

1995

Phytomedicine

744

24

Trends in use of complementary and alternative medicine by us adults: 1997–2002

Tindle H.A., Davis R.B., Phillips R.S., Eisenberg D.M.

2005

Alternative Therapies in Health and Medicine

724

25

Antioxidant principles from Bauhinia tarapotensis

Braca A., De Tommasi N., Di Bari L., Pizza C., Politi M., Morelli I.

2001

Journal of Natural Products

712

26

Synergy research: Approaching a new generation of phytopharmaceuticals

Wagner H., Ulrich-Merzenich G.

2009

Phytomedicine

695

27

Safety and anti-inflammatory activity of curcumin: A component of tumeric (Curcuma longa)

Chainani-Wu N.

2003

Journal of Alternative and Complementary Medicine

683

28

Natural products from plant-associated microorganisms: Distribution, structural diversity, bioactivity, and implications of their occurrence

Gunatilaka A.A.L.

2006

Journal of Natural Products

664

29

The pharmacological potential of mushrooms

Lindequist U., Niedermeyer T.H.J., Jülich W.-D.

2005

Evidence-based Complementary and Alternative Medicine

648

30

Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation

Houghton P.J., Zarka R., De Las Heras B., Hoult J.R.S.

1995

Planta Medica

641

31

Marine natural products and related compounds in clinical and advanced preclinical trials

Newman D.J., Cragg G.M.

2004

Journal of Natural Products

626

32

Synergy and other interactions in phytomedicines

Williamson E.M.

2001

Phytomedicine

621

33

Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals

Surh Y.-J., Kundu J.K., Na H.-K.

2008

Planta Medica

593

34

Use and expenditure on complementary medicine in England: A population based survey

Thomas K.J., Nicholl J.P., Coleman P.

2001

Complementary Therapies in Medicine

577

35

In vitro antibacterial activity of some plant essential oils

Prabuseenivasan S., Jayakumar M., Ignacimuthu S.

2006

BMC Complementary and Alternative Medicine

572

36

Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries

Wang H., Nair M.G., Strasburg G.M., Chang Y.-C., Booren A.M., Gray J.I., DeWitt D.L.

1999

Journal of Natural Products

572

37

Alkaloids from amphibian skin: A tabulation of over eight-hundred compounds

Daly J.W., Spande T.F., Garraffo H.M.

2005

Journal of Natural Products

558

38

Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): A review

Mishra L.-C., Singh B.B., Dagenais S.

2000

Alternative Medicine Review

538

39

Acetylcholinesterase inhibitors from plants

Mukherjee P.K., Kumar V., Mal M., Houghton P.J.

2007

Phytomedicine

522

40

Extraction, isolation and characterization of bioactive compounds from plants’ extracts

Sasidharan S., Chen Y., Saravanan D., Sundram K.M., Yoga Latha L.

2011

African Journal of Traditional, Complementary and Alternative Medicines

514

41

Annonaceous acetogenins: A review

Rupprecht J.K., Hui Y.-H., McLaughlin J.L.

1990

Journal of Natural Products

498

42

Synergism between natural products and antibiotics against infectious diseases

Hemaiswarya S., Kruthiventi A.K., Doble M.

2008

Phytomedicine

489

43

Lead toxicity, a review of the literature. Part I: Exposure, evaluation, and treatment

Patrick L.

2006

Alternative Medicine Review

481

44

Complementary and alternative medicine use in Australia: A national population-based survey

Xue C.C.L., Zhang A.L., Lin V., Da Costa C., Story D.F.

2007

Journal of Alternative and Complementary Medicine

460

45

Traditional Chinese medicine network pharmacology: Theory, methodology and application

Li S., Zhang B.

2013

Chinese Journal of Natural Medicines

455

46

Beneficial effects of green tea: A literature review

Chacko S.M., Thambi P.T., Kuttan R., Nishigaki I.

2010

Chinese Medicine

454

47

Therapeutic applications of pomegranate (Punica granatum L.): A review

Jurenka J.

2008

Alternative Medicine Review

451

48

Recent extraction techniques for natural products: Microwave-assisted extraction and pressurised solvent extraction

Kaufmann B., Christen P.

2002

Phytochemical Analysis

447

49

Astaxanthin, a carotenoid with potential in human health and nutrition

Hussein G., Sankawa U., Goto H., Matsumoto K., Watanabe H.

2006

Journal of Natural Products

429

50

Antimicrobial activity of essential oils: A 1976–1986 literature review. Aspects of the test methods

Janssen A.M., Scheffer J.J.C., Baerheim Svendsen A.

1987

Planta Medica

429

51

Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L

Saeed N., Khan M.R., Shabbir M.

2012

BMC Complementary and Alternative Medicine

426

52

Clinical applications of N-acetylcysteine

Kelly G.S.

1998

Alternative Medicine Review

422

53

Nutritional quality of organic versus conventional fruits, vegetables, and grains

Worthington V.

2001

Journal of Alternative and Complementary Medicine

421

54

Chemotherapy-associated oxidative stress: Impact on chemotherapeutic effectiveness

Conklin K.A.

2004

Integrative Cancer Therapies

419

55

Iridoids. A review

El-Naggar L.J., Beal J.L.

1980

Journal of Natural Products

418

56

Anti-aids agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids

Fujioka T., Kashiwada Y., Kilkuskie R.E., Cosentino L.M., Bailas L.M., Jiang J.B., Janzen W.P., Chen I.-S., Lee K.-H.

1994

Journal of Natural Products

415

57

Bleomycin: New perspectives on the mechanism of action

Hecht S.M.

2000

Journal of Natural Products

406

58

Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection

Vlietinck A.J., De Bruyne T., Apers S., Pieters L.A.

1998

Planta Medica

404

59

Antioxidants and cancer III: Quercetin

Lamson D.W., Brignall M.S.

2000

Alternative Medicine Review

403

60

A microwell cytotoxicity assay using Artemia salina (brine shrimp)

Solis P.N., Wright C.W., Anderson M.M., Gupta M.P., Phillipson J.D.

1993

Planta Medica

403

61

How many cancer patients use complementary and alternative medicine: A systematic review and metaanalysis

Horneber M., Bueschel G., Dennert G., Less D., Ritter E., Zwahlen M.

2012

Integrative Cancer Therapies

395

62

The BBC survey of complementary medicine use in the UK

Ernst E., White A.

2000

Complementary Therapies in Medicine

395

63

The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis part I

Zhu J.-S., Halpern G.M., Jones K.

1998

Journal of Alternative and Complementary Medicine

389

64

Therapeutic applications of whey protein

Marshall K.

2004

Alternative Medicine Review

383

65

Chemical toxins: A hypothesis to explain the global obesity epidemic

Baillie-Hamilton P.F.

2002

Journal of Alternative and Complementary Medicine

377

66

Quantitative 1H NMR: Development and potential of a method for natural products analysis

Pauli G.F., Jaki B.U., Lankin D.C.

2005

Journal of Natural Products

376

67

Antimicrobial activity of some ethnomedicinal plants used by Paliyar tribe from Tamil Nadu, India

Duraipandiyan V., Ayyanar M., Ignacimuthu S.

2006

BMC Complementary and Alternative Medicine

375

68

Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity

Potterat O.

2010

Planta Medica

374

69

Constituents of Cannabis sativa L. XVII. a review of the natural constituents

Turner C.E., Elsohly M.A., Boeren E.G.

1980

Journal of Natural Products

373

70

Recent natural products based drug development: A pharmaceutical industry perspective

Shu Y.-Z.

1998

Journal of Natural Products

371

71

Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries

Seeram N.P., Momin R.A., Nair M.G., Bourquin L.D.

2001

Phytomedicine

370

72

Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles

Chrubasik S., Pittler M.H., Roufogalis B.D.

2005

Phytomedicine

368

73

Ayurveda and traditional Chinese medicine: A comparative overview

Patwardhan B., Warude D., Pushpangadan P., Bhatt N.

2005

Evidence-based Complementary and Alternative Medicine

366

74

A-type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli

Foo L.Y., Lu Y., Howell A.B., Vorsa N.

2000

Journal of Natural Products

366

75

Historical review of medicinal plants’ usage

Petrovska B.B.

2012

Pharmacognosy Reviews

363

76

Plant sources of hepatotoxic pyrrolizidine alkaloids

Smith L.W., Culvenor C.C.J.

1981

Journal of Natural Products

361

77

Steaming of ginseng at high temperature enhances biological activity

Wang Yu Kim, Jong Moon Kim, Sang Beom Han, Seung Ki Lee, Nak Doo Kim, Park M.K., Chong Kook Kim, Park J.H.

2000

Journal of Natural Products

360

78

Recent trends and important developments in propolis research

Bankova V.

2005

Evidence-based Complementary and Alternative Medicine

357

79

Therapeutic applications of fenugreek

Basch E., Ulbricht C., Kuo G., Szapary P., Smith M.

2003

Alternative Medicine Review

357

80

Antioxidant and free radical scavenging activity of Spondias pinnata

Hazra B., Biswas S., Mandal N.

2008

BMC Complementary and Alternative Medicine

354

81

Antioxidant and radical scavenging effects of aged garlic extract and its constituents

Imai J., Ide N., Nagae S., Moriguchi T., Matsuura H., Itakura Y.

1994

Planta Medica

350

82

Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy

Laszczyk M.N.

2009

Planta Medica

346

83

Antioxidant and antimicrobial activity of Foeniculum vulgare and crithmum maritimum essential oils

Ruberto G., Baratta M.T., Deans S.G., Dorman H.J.D.

2000

Planta Medica

346

84

Medicinal plants used by traditional healers in Kancheepuram District of Tamil Nadu, India

Muthu C., Ayyanar M., Raja N., Ignacimuthu S.

2006

Journal of Ethnobiology and Ethnomedicine

344

85

Lead toxicity part II: The role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity

Patrick L.

2006

Alternative Medicine Review

343

86

A rapid and effective method for RNA extraction from different tissues of grapevine and other woody plants

Gambino G., Perrone I., Gribaudo I.

2008

Phytochemical Analysis

341

87

Benefits and requirements of vitamin D for optimal health: A review

Grant W.B., Holick M.F.

2005

Alternative Medicine Review

341

88

Antimicrobial and antioxidant activities of three Mentha species essential oils

Mimica-Dukić N., Božin B., Soković M., Mihajlović B., Matavulj M.

2003

Planta Medica

338

89

The taxane diterpenoids

Baloglu E., Kingston D.G.I.

1999

Journal of Natural Products

337

90

Flavonoids: A versatile source of anticancer drugs

Chahar M.K., Sharma N., Dobhal M.P., Joshi Y.C.

2011

Pharmacognosy Reviews

332

91

Resilience: A historical review of the construct

Tusaie K., Dyer J.

2004

Holistic Nursing Practice

332

92

α-glucosidase inhibitors from plants: A natural approach to treat diabetes

Kumar S., Narwal S., Kumar V., Prakash O.

2011

Pharmacognosy Reviews

331

93

Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test

Butterweck V., Jürgenliemk G., Nahrstedt A., Winterhoff H.

2000

Planta Medica

328

94

Stigmasterols from Typha latifolia

Greca M.D., Monaco P., Previtera L.

1990

Journal of Natural Products

327

95

Flavonoids and phenolic acids: Role and biochemical activity in plants and human

Ghasemzadeh A., Ghasemzadeh N.

2011

Journal of Medicinal Plant Research

326

96

Alternative antimicrobial approach: Nano-antimicrobial materials

Beyth N., Houri-Haddad Y., Domb A., Khan W., Hazan R.

2015

Evidence-based Complementary and Alternative Medicine

324

97

Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils

Peana A.T., D’Aquila P.S., Panin F., Serra G., Pippia P., Moretti M.D.L.

2002

Phytomedicine

324

98

Immunostimulant agents from Andrographis paniculata

Puri A., Saxena R., Saxena R.P., Saxena K.C., Srivastava V., Tandon J.S.

1993

Journal of Natural Products

324

99

The health benefits of yoga and exercise: A review of comparison studies

Ross A., Thomas S.

2010

Journal of Alternative and Complementary Medicine

320

100

Anti-inflammatory compounds of plant origin. Part II. Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules

Calixto J.B., Campos M.M., Otuki M.F., Santos A.R.S.

2004

Planta Medica

319