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Table 3 Antiplasmodial activity and cytotoxicity of isolated compounds from selected fractions

From: Identification of 3,3′-O-dimethylellagic acid and apigenin as the main antiplasmodial constituents of Endodesmia calophylloides Benth and Hymenostegia afzelii (Oliver.) Harms

Plant species

Fractions

Compounds

EC50 (μM)

RI

CC50 (μM)

SI

 

Vero

Raw

 

Pf3D7

PfDd2

Vero

Raw

Pf3D7 (PfDd2)

Pf3D7 (PfDd2)

H. afzelii

F4

1

19.01 ± 0.72

16.39 ± 0.52

0.86

> 185.02

> 185.02

> 9.73(> 11.29)

> 9.73(> 11.29)

 

2

I

I

  

3

I

I

 

4

I

I

  

5a

NT

NT

NT

NT

E. calophylloides

F8

6

4.27 ± 0.05

1.36 ± 0.47

0.32

> 151.52

> 151.52

> 35.48(> 111.41)

> 35.48(> 111.41)

Reference drugs

Artemisinin

 

0.014 ± 0.001

0.018 ± 0.003

1.26

NA

NA

Chloroquine

 

0.018 ± 0.002

0.449 ± 0.065

24.86

NA

NA

 

Podophyllotoxin

 

NA

NA

 

4.56 ± 0.92

1.83 ± 0.22

  1. Results are expressed as means ± standard deviation of duplicate experiments
  2. NT not tested; a: This compound wasn’t tested due to the quantity; I inactive, NA not applicable, EC50 50% effective concentration; CC50 50% cytotoxicity concentration, RI resistance index, SI selectivity index