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Table 2 Characteristics of included studies

From: The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials

First author (publication year)

Country

Number and gender (F/M)

Study participants health condition

Mean age

Clinical Trial design /randomized/Blinding

Duration

Comparison group

Amount of vinegar intake

Reported outcomes

Bashiri et al. (2014) [4]

Iran

Number: 62

(Both gender)

Type 2 diabetic patients with dyslipidemia

Range: 25–65

Intervention:

49.47 ± 8.02

Placebo:

52.1 ± 7.87

Parallel/ Yes/No

8 weeks

–

20 mL/day

TG

TC

HDL

LDL

Halima et al. (2017) [16]

Tunisia

Number: 44

(NR)

Type 2 diabetes

range: 40–65

Intervention: NR

Placebo: NR

Parallel/ Yes/ Yes

1 month

water

15 mL/day

FPG

TG

TC

HDL

LDL

Kondo et al. (2009) [23]

Japan

Number: 155

(Both gender)

Obese

Range:25–60

Intervention (high-dose):

43.4 ± 9.5

Intervention (low-dose):

44.7 ± 9.7

Placebo:

44.1 ± 9.6

Parallel/ Yes/ Yes

12 weeks

Beverage

15 mL/day

TG

TC

HDL-C

LDL-C

FPG

HbA1C

30 mL/day

Mahmoodi et al. (2013) [27]

Iran

Number: 60

(Both gender)

Type 2 diabetic

Range:30–60

Parallel/ NR/ Yes

1 month

Water

15 mL/day

TG

TC

HDL-C

LDL-C

FPG

HbA1C

Panetta et al. (2013) [33]

USA

Number: 97

(Both gender)

NR

Intervention:

57.7 ± 9.33

Placebo:

56.1 ± 12.58

Parallel/ Yes/ Yes

8 weeks

Balsamic vinegar solution diluted in water

30 mL/day

TG

TC

HDL-C

LDL-C

HbA1C

Khezri et al. (2018) [22]

Iran

Number: 44

(Both gender)

Obese and overweight

Range: 27–40

Intervention:

42.5 ± 9

Placebo:

45 ± 11

Parallel/ Yes/ No

12 weeks

Restricted calorie diet

30 mL/day plus restricted calorie diet.

TG

TC

HDL-C

LDL-C

Ebrahimi-Mamaghani et al. (2009) [12]

Iran

Number: 38

(Both gender)

Type 2 diabetic

Intervention:

54.6 ± 13.1

Placebo:

53.8 ± 9.0

Parallel/ Yes/ No

8 weeks

–

770 mL/day

TG

TC

HDL-C

LDL-C

FPG

Mohammadpourhodki et al. (2019) [28]

Iran

Number: 76

(Both gender)

Type 2 diabetes

Range: 18–65

Intervention:

49.2 ± 4.3

Placebo:

49.2 ± 4.3

Parallel/ Yes/No

8 weeks

Water

20 mL/day

FPG

HbA1C

Kausar et al. (2019) [20]

Pakistan

Number: 110 (Both gender)

Type 2 diabetes

Range: 30–60

Intervention:

51.16 ± 7.91

Placebo:

50.49 ± 7.78

Parallel/ Yes/Yes

3 month

Water with artificial flavor

15 mL/day

TG

TC

HDL-C

LDL-C

FPG

HbA1C

  1. Abbreviations: TG triacylglycerol, TC total-cholesterol, LDL-C Low-density lipoprotein cholesterol, HDL-C High-density lipoprotein cholesterol, FPG Fasting plasma glucose, HbA1C hemoglobin A1C, NR Not Reported