Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae)

Table 4 Damage levels observed on J774A.1 macrophages treated with a matrix of pharmacological interactions

Mixture	Damage Level										Damage index (DI)		% Total damage		p
	Type 0		Type 1		Type 2		Type 3		Type 4		Damage index (DI)		% Total damage
	%	SD	%	SD	%	SD	%	SD	%	SD	%	SD	%	SD
BZN	0	0	1	0.2	7.3	1.2	89	1.7	2.7	1.3	293	3.1	98	0.01	Ref
3	36	3.1	53	3.5	8	1.5	3	1.3	0	0	79	7.5	45	0.02	0.0001
4	57	4.6	41	3.0	2	0.7	0	0	0	0	45	6.2	36	0.02	0.0001
5	26	2.6	71	1.5	3	0.5	0	0	0	0	77	4.4	44	0.01	0.0001
10	41	2.1	54	2.6	4	1.2	1	0.1	0	0	66	1.5	41	0.004	0.0001
11	10	4	49	2.1	34	2.0	7	2.5	0	0	137	7.6	59	0.02	0.0001
12	5.7	1.5	90	1.5	4	1.2	0.3	0	0	0	99	3.2	50	0.008	0.0001

SD standard deviation, Mixtures 3, 4, and 5: different combinations of ACT1 + ACT2 as described in Table 2; Mixtures 10, 11, and 12: different combinations of ACT1 + BNZ as described in Table 2; ACT1: limonene-enriched fraction from Carvone-chemotype of Lippia alba; ACT2: citral/caryophyllene oxide-enriched fraction from Carvone-chemotype of Lippia alba; BZN Benznidazole

ISSN: 2662-7671