Table 1 Matrix of pharmacological interactions tested on amastigotes of Trypanosoma cruzi or J774A.1 macrophage cell
Mixture | Factorial combinations IC50 or CC50 Values | Equivalent Compound Concentration | ||||
|---|---|---|---|---|---|---|
ACT1 | ACT2 | BZN | ACT1 (μg/mL) | ACT2 (μg/mL) | BZN (μg/mL) | |
1 | 0 | 8X IC50/CC50 | – | 640/1704 | ||
2 | ½X IC50/CC50 | 4X IC50/CC50 | 22.5/229 | 320/852 | ||
3 | 1X IC50/CC50 | 2X IC50/CC50 | 45/458 | 160/426 | ||
4 | 2X IC50/CC50 | 1X IC50/CC50 | 90/916 | 80/213 | ||
5 | 4X IC50/CC50 | ½X IC50/CC50 | 180/1832 | 40/106.5 | ||
6 | 8X IC50/CC50 | 0 | 360/3664 | – | ||
7 | 0 | 8X IC50/CC50 | – | 384/2388 | ||
8 | ½X IC50−CC50 | 4X IC50/CC50 | 22.5/229 | 192/1194 | ||
9 | 1X IC50/CC50 | 2X IC50/CC50 | 45/458 | 96/597 | ||
10 | 2X IC50/CC50 | 1X IC50/CC50 | 90/916 | 48/298.5 | ||
11 | 4X IC50/CC50 | ½X IC50/CC50 | 180/1832 | 24/149.3 | ||
12 | 8X IC50/CC50 | 0 | 360/3664 | – | ||