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Fig. 8 | BMC Complementary Medicine and Therapies

Fig. 8

From: Ameliorated biomechanical properties of carotid arteries by puerarin in spontaneously hypertensive rats

Fig. 8

Underlying effect and possible mechanism of PUE on blood pressure and vascular remodeling involving Ca2+ in hypertension. The mechanism by which PUE reduced blood pressure was mainly related to BKCa activation, VGCC inactivation and SERCA activation. The mechanism by which PUE ameliorated vascular remodeling was mainly related to TRPCs inactivation, regulating the Ca2+-CaN-NFAT pathway and Ca2+-PKC-NFκB pathway. BKCa: large-conductance voltage- and Ca2+-activated potassium channel; VGCC: Voltage gated calcium channels; SERCA: sarco endoplasmic reticulum Ca2+-ATPase; CaM: Calmodulin; CaN: Calcineurin; PKC: protein kinase C; GPCR: G protein coupled receptor; PLC: phospholipase C

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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