Table 2 Percentage of IL-1β-induced HFLS-RA cell population after 24 h of treatment with ACRH, QRF, and BQ respectively

Negative control

–

68.9 ± 0.4^a

4.2 ± 0.5^a

22.8 ± 1.9^a

3.6 ± 0.2^ab

Vehicle (0.1% DMSO)

–

77.2 ± 0.0^a

4.6 ± 0.1^a

15.1 ± 0.3^a

3.2 ± 0.1^ab

Suramin

50

74.1 ± 1.4^a

6.3 ± 0.8^ab

17.3 ± 1.8^a

2.2 ± 0.1^a

ACRH

0.05

67.2 ± 2.4^a

4.0 ± 0.8^a

23.4 ± 0.1^a

4.0 ± 0.5^ab

0.5

76.3 ± 0.9^a

4.5 ± 0.4^a

15.5 ± 0.3^a

4.5 ± 0.2^b

5

26.8 ± 14.6^b

22.7 ± 1.1^c

50.1 ± 8.6^b

5.0 ± 1.6^b

QRF

0.05

73.6 ± 0.1^a

3.9 ± 1.1^a

17.3 ± 1.2^a

3.3 ± 0.6^ab

0.5

75.7 ± 0.2^a

5.9 ± 0.1^ab

14.3 ± 0.0^a

4.0 ± 0.1^ab

5

69.0 ± 0.9^a

5.4 ± 0.1^ab

19.8 ± 1.6^a

4.4 ± 0.3^ab

BQ

0.05

75.0 ± 1.3^a

6.3 ± 0.4^ab

15.2 ± 1.5^a

3.8 ± 0.1^ab

0.5

75.0 ± 0.8^a

5.9 ± 0.8^ab

15.0 ± 0.5^a

3.4 ± 0.6^ab

5

4.4 ± 2.1^c

8.6 ± 1.7^b

77.6 ± 6.0^c

5.1 ± 0.5^b