Table 3 Mapping of targeted signaling pathways on canonical oncogenic pathways based on related cancer pathophysiologic processes
Drug | Carcinogenesis process | ||||
|---|---|---|---|---|---|
Cell Line | Activity | Cell cycle/Proliferation and Apoptosis | Metastasis and invasion | Angiogenesis | |
ACT | MDA-MB- 453 | Down | Intrinsic Pathway for Apoptosis PTK6 Regulates Cell Cycle Interferon Signaling | – | – |
Up | PI3K-Akt-mTOR NRF2 pathway TGF-beta Signaling Pathway | – | – | ||
CKI | MCF-7 | Down | p53 signaling pathway regulation of intrinsic apoptotic signaling pathway | – | – |
Up | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities EGF/EGFR Signaling Pathway NRF2 pathway Fc epsilon RI signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway | Canonical and Non-Canonical TGF-B signaling | VEGFA-VEGFR2 Signaling Pathway | ||
WA | MCF-7 | Down | p53 signaling pathway NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and − 10 Interferon Signaling Cytokine Signaling in Immune system | – | TGF-beta Signaling Pathway |
Up | NRF2 pathway MAPK Signaling Pathway p53 signaling pathway intrinsic apoptotic signaling pathway | – | – | ||
MDA-MB-231 | Down | NRF2 pathway MAPK signaling pathway ErbB Signaling Pathway p53 signaling pathway TGF-beta Signaling Pathway Notch Signaling Pathway IL-4 Signaling Pathway IL17 signaling pathway | TCF dependent signaling in response to WNT | – | |
Up | PI3K-Akt Signaling Pathway Interferon Signaling TNF signaling pathway | Inflammatory Response Pathway | VEGFA-VEGFR2 Signaling Pathway Notch (U) TGF-beta Signaling Pathway | ||
I3C | MCF-7 | Down | TP53 Regulates Transcription of Cell Cycle Genes Signaling by EGFR Apoptosis PI3K-AKT-mTOR signaling pathway and therapeutic opportunities MAPK Signaling Pathway Wnt Signaling Pathway and Pluripotency T-Cell Receptor and Co-stimulatory Signaling TNF alpha Signaling Pathway | TGF-beta Receptor Signaling | – |
Up | Apoptosis regulation of cell cycle | – | – | ||
T47D | Down | Cell Cycle, Mitotic ErbB Signaling Pathway PI3K-Akt Signaling Pathway Chemokine signaling pathway | Signaling by NOTCH1 in Cancer Wnt Signaling Pathway and Pluripotency TGF-beta Signaling Pathway | VEGFA-VEGFR2 Signaling Pathway PDGF Pathway | |
Up | RIG-I-like Receptor Signaling Apoptosis MAPK Signaling Pathway Interferon gamma signaling TGF-beta Signaling Pathway | – | – | ||
ZR751 | Down | EGF/EGFR Signaling Pathway Notch Signaling Pathway TGF-beta Signaling Pathway regulation of apoptotic process Negative regulators of RIG-I/MDA5 signaling | Wnt Signaling Pathway and Pluripotency | VEGFA-VEGFR2 Signaling Pathway | |
Up | Interferon Signaling NRF2 pathway Apoptosis MAPK Signaling Pathway | – | – | ||
MDA-MB-231 | Down | – | Pathways Regulating Hippo Signaling | VEGFA-VEGFR2 Signaling Pathway | |
Up | NRF2 pathway | – | – | ||
MDA-MB-436 | Down | ErbB Signaling Pathway PI3K-Akt Signaling Pathway MAPK Signaling Pathway | Wnt Signaling Pathway and Pluripotency Hippo(D) T-Cell Receptor and Co-stimulatory Signaling | PDGF(D) TGF-beta Signaling Pathway | |
Up | Apoptosis-related network due to altered Notch3 in ovarian cancer TGF-beta Signaling Pathway Activated TLR4 signalling | – | – | ||