Fig. 1

Effect of STW 5 treatment on colon length, colon mass index, and histopathological changes, in colonic tissue of rats with DSS-induced colitis. Induction of colitis led to a reduction in colon length A as compared to the vehicle control group and this was associated with an increase in colon mass index B. Normal histological structure of colonic mucosa in normal control rats C. Colon of rats with DSS-induced colitis showing necrosis of epithelium, distortion of crypts, inflammatory infiltrate in lamina propria as well as sub-mucosal edema D. Apparently normal mucosa in the colon of rats with DSS-induced colitis after treatmet with STW 5 which tended to prevent these changes E. Data represented as means ± standard deviation of at least two independent experiments with number of animals of at least 14 animals per group