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Table 7 Cytotoxic potential of Aquilegia pubiflora plant extracts against the promastigote and amastigote forms of Leishmania tropica (KWH23)

From: Phytochemical analysis and versatile in vitro evaluation of antimicrobial, cytotoxic and enzyme inhibition potential of different extracts of traditionally used Aquilegia pubiflora Wall. Ex Royle

L. tropica

Sample

 

Concentration

25 μg/mL

50 μg/mL

100 μg/mL

200 μg/mL

400 μg/mL

+ control

IC50

Promastigote

APDW

16.7 ± 0.40***

21.3 ± 0.61**

26.4 ± 0.74**

40.7 ± 0.86*

44.1 ± 1.1*

73.1 ± 1.3

443

APM

14.2 ± 0.51***

24.8 ± 0.63***

31.6 ± 0.70**

41.3 ± 0.91*

47 ± 0.9*

78.8 ± 1.7

410

APE

20 ± 0.52***

24.5 ± 0.56***

37.2 ± 0.79**

45.3 ± 0.82*

52 ± 1.2*

75.2 ± 1.2

376

APEA

17.1 ± 0.51***

28.1 ± 0.50**

35.8 ± 0.81**

40.4 ± 0.73*

46.4 ± 0.81*

75.4 ± 1.1

471

Amastigote

APDW

19.4 ± 0.53***

32.8 ± 0.97**

28.9 ± 0.72***

39.6 ± 0.61*

47.4 ± 0.82*

78.7 ± 1.6

464

APM

19.9 ± 0.63***

26.9 ± 0.41***

32.5 ± 0.86**

41.1 ± 0.69*

51 ± 0.9*

78.1 ± 1.6

381

APE

20.1 ± 0.64***

31.1 ± 0.69***

44.6 ± 1.1**

51.1 ± 0.83*

59 ± 1.1*

73.9 ± 1.5

344

APEA

21.4 ± 0.44***

33.8 ± 0.55**

37.8 ± 0.78**

42.3 ± 0.78*

49.1 ± 0.71*

74.9 ± 1.1

425

  1. Star *–*** represent; *** highly significant, ** slightly significant and * non-significant difference from control at P < 0.05 by one-way ANOVA in the column. Values are mean ± SD of triplicate. Where APDW, APM, APE and APEA stands for Distilled water, Methanol, Ethanol and Ethyl acetate extracts, respectively