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Table 7 Cytotoxic potential of Aquilegia pubiflora plant extracts against the promastigote and amastigote forms of Leishmania tropica (KWH23)

From: Phytochemical analysis and versatile in vitro evaluation of antimicrobial, cytotoxic and enzyme inhibition potential of different extracts of traditionally used Aquilegia pubiflora Wall. Ex Royle

L. tropica Sample   Concentration
25 μg/mL 50 μg/mL 100 μg/mL 200 μg/mL 400 μg/mL + control IC50
Promastigote APDW 16.7 ± 0.40*** 21.3 ± 0.61** 26.4 ± 0.74** 40.7 ± 0.86* 44.1 ± 1.1* 73.1 ± 1.3 443
APM 14.2 ± 0.51*** 24.8 ± 0.63*** 31.6 ± 0.70** 41.3 ± 0.91* 47 ± 0.9* 78.8 ± 1.7 410
APE 20 ± 0.52*** 24.5 ± 0.56*** 37.2 ± 0.79** 45.3 ± 0.82* 52 ± 1.2* 75.2 ± 1.2 376
APEA 17.1 ± 0.51*** 28.1 ± 0.50** 35.8 ± 0.81** 40.4 ± 0.73* 46.4 ± 0.81* 75.4 ± 1.1 471
Amastigote APDW 19.4 ± 0.53*** 32.8 ± 0.97** 28.9 ± 0.72*** 39.6 ± 0.61* 47.4 ± 0.82* 78.7 ± 1.6 464
APM 19.9 ± 0.63*** 26.9 ± 0.41*** 32.5 ± 0.86** 41.1 ± 0.69* 51 ± 0.9* 78.1 ± 1.6 381
APE 20.1 ± 0.64*** 31.1 ± 0.69*** 44.6 ± 1.1** 51.1 ± 0.83* 59 ± 1.1* 73.9 ± 1.5 344
APEA 21.4 ± 0.44*** 33.8 ± 0.55** 37.8 ± 0.78** 42.3 ± 0.78* 49.1 ± 0.71* 74.9 ± 1.1 425
  1. Star *–*** represent; *** highly significant, ** slightly significant and * non-significant difference from control at P < 0.05 by one-way ANOVA in the column. Values are mean ± SD of triplicate. Where APDW, APM, APE and APEA stands for Distilled water, Methanol, Ethanol and Ethyl acetate extracts, respectively