Skip to main content

Table 6 AChE and BChE inhibitory potential of plant extracts

From: Phytochemical analysis and versatile in vitro evaluation of antimicrobial, cytotoxic and enzyme inhibition potential of different extracts of traditionally used Aquilegia pubiflora Wall. Ex Royle

Enzymes

Sample

 

Concentration

25 μg/mL

50 μg/mL

100 μg/mL

200 μg/mL

400 μg/mL

+ control

IC50

AChE

APDW

31.7 ± 0.70***

39.2 ± 0.66***

47.5 ± 0.80***

62.7 ± 1.2*

76.3 ± 1.1*

91.2 ± 2.1

193

APM

34.2 ± 0.81***

44.6 ± 1.4**

51.7 ± 0.86*

59.1 ± 0.92*

68.5 ± 1.2*

87.1 ± 2.2

98

APE

27.8 ± 0.69***

34.9 ± 0.61**

57.4 ± 0.92*

68.3 ± 1.2*

81.5 ± 1.6*

88.9 ± 1.9

91

APEA

27.6 ± 0.31***

38.7 ± 0.50**

45.3 ± 0.73**

57.4 ± 0.81**

71.3 ± 0.81*

84.2 ± 1.7

163

BChE

APDW

34.7 ± 0.93***

42.2 ± 0.62**

49.7 ± 1.2**

66 ± 0.91*

77.4 ± 0.99*

91.6 ± 1.9

154

APM

31.9 ± 0.60***

36.5 ± 0.48***

42.7 ± 0.72**

61.1 ± 0.79*

72.1 ± 1.3*

90.3 ± 1.9

121

APE

38.2 ± 0.74***

41.9 ± 0.59**

54.2 ± 1.4**

71.4 ± 0.93*

83.9 ± 1.4*

92.1 ± 1.8

84

APEA

31.1 ± 0.34**

43.1 ± 0.75**

57.3 ± 0.88*

61.6 ± 0.71*

67.1 ± 0.73*

87.3 ± 1.7

95

  1. Star *–*** represent; *** highly significant, ** slightly significant and * non-significant difference from the control at P < 0.05 by one-way ANOVA in the column. Values are mean ± SD of triplicate. Where APDW, APM, APE and APEA stands for Distilled water, Methanol, Ethanol and Ethyl acetate extracts, respectively