Fig. 4

Effect of silibinin on cell migration. A) The migration capability of CT26 cells was evaluated by a scratch assay after 0, 24, 48 and 72 h of treatment with different dose of silibinin. B) RT-qPCR analysis of MMP-2, MMP-9, CCR-2 and CXCR-4 expression in cells treated with silibinin and untreated cells after 24 h of treatment. Data are represented as mean ± standard error of the mean (n = 3). **P < 0.01 and ***P < 0.001 versus control group