Antibacterial, antifungal and antioxidant activities of whole plant chemical constituents of Rumex abyssinicus

Table 2 Interactions of the methanol extract/compounds from R. abyssinicus and antibiotics against bacterial and yeast species

Microorganisms	MeOH extract				Compound 2				Compound 4
Microorganisms	FICA	FICEx	FIC	Interpretation	FICA	FIC2	FIC	Interpretation	FICA	FIC5	FIC	Interpretation
P. aeruginosa	0.25	0.125	0.37	Synergistic	0.125	0.125	0.25	Synergistic	0.25	0.125	0.25	Synergistic
S. flexneri	0.125	0.125	0.25	Synergistic	0.031	0.25	0.281	Synergistic	0.0625	0.25	0.31	Synergistic
S. aureus	0.25	0.125	0.37	Synergistic	0.25	0.125	0.375	Synergistic	0.5	0.125	0.625	Additive
MSSA01	0.125	0.0625	0.18	Synergistic	0.0625	0.5	0.5625	Additive	0.25	0.25	0.5	Synergistic
MRSA03	0.125	0.125	025	Synergistic	0.0625	0.5	0.5625	Additive	0.25	0.125	0.375	Synergistic
C. albicans	0.125	0.0625	0.18	Synergistic	0.0625	0.0625	0.125	Synergistic	0.25	0.5	0.75	Additive
C. neoformans	0.0625	0.0625	0.125	Synergistic	0.0625	0.0625	0.125	Synergistic	0.25	0.5	0.75	Additive

FICA MIC of antibiotic tested in combination/MIC of antibiotic tested alone; FICEx MIC of extract tested in combination/MIC of extract tested alone; FIC2 MIC of compound 2 tested in combination with antibiotic/ MIC of compound 2 tested alone; FIC4 MIC of compound 4 tested in combination with antibiotic/ MIC of compound 4 tested alone; FIC: MIC of antibiotic tested in combination/MIC of antibiotic tested alone + MIC of extract/compound tested in combination/MIC of extract/compound tested alone; antibiotics: ciprofloxacin for bacteria and fluconazole for yeasts

ISSN: 2662-7671