Fig. 1

Chondrocytes were stimulated with IL-1β to construct OA model in vitro. a, b Cell viability was measured by CCK-8 method after CHON-001 and ATDC5 cells were treated with 0, 1, 5, 10 ng / mL IL-1β for 24 h. c CHON-001 and ATDC5 cell lines were treated with 0, 1, 5, 10 ng / mL IL-1β, and the apoptosis of CHON-001 and ATDC5 cells was detected by flow cytometry. d-f CHON-001 and ATDC5 cell lines were treated with 0,1,5 and 10 ng/mL IL-1β, and the contents of IL-6, IL-8 and TNF-α were detected by ELISA. *P < 0.05, **P < 0.01, ***P < 0.001 vs. control group.