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Table 2 HIV-1 reverse transcriptase activity and anti-inflammatory properties of some fermented herbal concoctions sold in Limpopo

From: Exploring the anti-HIV-1 reverse transcriptase, anti-inflammatory, anti-cancer activities and cytotoxicity of two fermented commercial herbal concoctions sold in Limpopo Province of South Africa

Sample

HIV-RT 1 (IC50 μg/mL)

sPLA2 (IC50 μg/mL)

15-LOX (IC50 μg/mL)

COX-1 (IC50 μg/mL).

COX-2 (IC50 μg/mL).

C1 (Crude)

64.4 ± 2.1b

70.4 ± 0.1a

88.2 ± 0.2a

2.11 ± 0.01d

18.00 ± 0.01d

C1 (80% Acetone)

39.5 ± 1.6de

25.1 ± 1.3b

67.2 ± 0.6d

5.43 ± 0.05b

27.60 ± 0.02b

C2 (Crude)

86.1 ± 1.8a

15.5 ± 0.6c

56.1 ± 0.3c

3.67 ± 0.02c

22.10 ± 0.01c

C2 (80% Acetone)

54.5 ± 1.5c

15.3 ± 0.5c

42.3 ± 0.1d

6.72 ± 0.01a

34.10 ± 0.01a

Lamivudine

41.0 ± 0.2d

    

Zidovudine

24.9 ± 0.6g

    

Lopinavir

33.8 ± 0.5f

    

Ritonavir

36.5 ± 0.3ef

    

Thioetheramide-PC

 

1.52 ± 0.1d

   

Nordihydroguairetic acid

  

10.8 ± 0.1e

  

Indomethacin

   

0.59 ± 0.01e

8.70 ± 0.10e

  1. C1- Concoction 1; C2- Concoction 2. Data are represented as means duplicates ± standard deviations. Different letters in columns are significantly different