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Table 4 Effects of plant extracts on the serum enzyme activity in relation to kidney stone treatment at 200 mg/kg extract dose on the 28th day post-treatment. The mixed extract = the combination of A. aspera, S. punctata and R. abyssinicus extracts (1:1:1 ratio). Data were presented as mean ± SD for 6 rats in each group (n = 6). Comparisons between means were made against Group I (vehicle control) and Group II (lithiatic control). *p < 0.05, **p < 0.01,***p < 0.001 indicate significant changes in comparison with group I (vehicle control), #p < 0.05, ##p < 0.01, ###p < 0.001 indicate significant changes in comparison with group II (lithiatic control)

From: Evaluations of the curative efficacy of G. fruticosus solvent extracts in experimentally induced nephrolithiatic Wistar male rats

Groups Treatments Enzyme Activity
ALT (IU/L) AST (IU/L)
I. Normal control (DH2O) 68.4 ± 5.04 113.1 ± 6.53
II. Lithiatic control 135.3 ± 14.13 211.0 ± 23.10
III. K-Cit (2.5 g/kg) 78.7 ± 6.10## 126.7 ± 8.11###
IV. Cystone (750 mg/kg) 67.8 ± 5.89## 161.3 ± 10.32*##
V. G. fruticosus PET extract 123.1 ± 11.05*** 225.1 ± 23.12***
VI. G. fruticosus Chl. extract 115.8 ± 7.01*** 208.7 ± 23.13***
VII. G. fruticosus EtOAc extract 78.7 ± 3.85*### 219.4 ± 27.60***
VIII. G. fruticosus BuOH extract 71.4 ± 5.16### 139.3 ± 9.54*###
IX. G. fruticosus aq. fraction 69.2 ± 4.11### 120.6. ± 11.32**###