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Table 4 Effects of plant extracts on the serum enzyme activity in relation to kidney stone treatment at 200 mg/kg extract dose on the 28th day post-treatment. The mixed extract = the combination of A. aspera, S. punctata and R. abyssinicus extracts (1:1:1 ratio). Data were presented as mean ± SD for 6 rats in each group (n = 6). Comparisons between means were made against Group I (vehicle control) and Group II (lithiatic control). *p < 0.05, **p < 0.01,***p < 0.001 indicate significant changes in comparison with group I (vehicle control), #p < 0.05, ##p < 0.01, ###p < 0.001 indicate significant changes in comparison with group II (lithiatic control)

From: Evaluations of the curative efficacy of G. fruticosus solvent extracts in experimentally induced nephrolithiatic Wistar male rats

Groups

Treatments

Enzyme Activity

ALT (IU/L)

AST (IU/L)

I.

Normal control (DH2O)

68.4 ± 5.04

113.1 ± 6.53

II.

Lithiatic control

135.3 ± 14.13

211.0 ± 23.10

III.

K-Cit (2.5 g/kg)

78.7 ± 6.10##

126.7 ± 8.11###

IV.

Cystone (750 mg/kg)

67.8 ± 5.89##

161.3 ± 10.32*##

V.

G. fruticosus PET extract

123.1 ± 11.05***

225.1 ± 23.12***

VI.

G. fruticosus Chl. extract

115.8 ± 7.01***

208.7 ± 23.13***

VII.

G. fruticosus EtOAc extract

78.7 ± 3.85*###

219.4 ± 27.60***

VIII.

G. fruticosus BuOH extract

71.4 ± 5.16###

139.3 ± 9.54*###

IX.

G. fruticosus aq. fraction

69.2 ± 4.11###

120.6. ± 11.32**###