Table 1 Antimalarial properties against P. falciparum K1 and 3D7 strains and the cytotoxicity of extracts and isolated compounds from D. bulbifera
Samples | IC50 (μM/nMd) | CC50 (μM) | |
|---|---|---|---|
K1 | 3D7 | ||
Ethanol extractc | 15.8 ± 3.18 | > 80 | >  80 |
Water extractc | > 80 | > 80 | >  80 |
8-Epidiosbulbin E acetate (1) | > 80 | > 80 | >  80 |
15,16-Epoxy-6α-O-acetyl-8β-hydroxy-19-nor-clero-13 (16),14-diene-17,12;18,2-diolide (2) | > 80 | > 80 | >  80 |
Sitosterol-β-D-glucoside (3) | > 80 | > 80 | >  80 |
3,5-Dimethoxyquercetin (4) | 44.03 ± 1.47a,b | 70.79 ± 2.32a,b | >  80 |
(+)-Catechin (5) | > 80 | > 80 | >  80 |
Quercetin (6) | 28.47 ± 0.90a,b | 50.99 ± 7.28a,b | >  80 |
Kaempferol (7) | 62.45 ± 1.33a,b | > 80 | >  80 |
Allantoin (8) | > 80 | > 80 | >  80 |
2,4,3′,5′-Tetrahydroxybibenzyl (9) | 39.99 ± 2.50a,b | 58.85 ± 4.31a,b | 16.71 |
2,4,6,7-Tetrahydroxy-9,10-dihydrophenanthrene (10) | 58.34 ± 1.96a,b | > 80 | >  80 |
Myricetin (11) | > 80 | > 80 | >  80 |
5,7,4′-Trihydroxy-2-styrylchromone (12) | > 80 | > 80 | >  80 |
Quercetin-3-O-β-D-glucopyranoside (13) | > 80 | > 80 | >  80 |
Quercetin-3-O-β-D-galactopyranoside (14) | 48.33 ± 1.21a,b | 68.93 ± 4.31a,b | >  80 |
Chloroquined | 103.2 ± 4.50 | 9.91 ± 0.56 | ND |
Artesunated | 0.53 ± 0.04 | 1.81 ± 0.19 | ND |
Doxorubicin | ND | ND | 1.96 ± 0.11 |