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Table 1 Antimicrobial activity of crude ethanolic flowers extract of N. oleander and different standard antibiotics against clinical isolates at different concentrations

From: A mechanistic study on the inhibition of bacterial growth and inflammation by Nerium oleander extract with comprehensive in vivo safety profile

Clinical isolates

Zone of inhibitions in mm

NOEE

Antibiotics

Control

(Water)

10 mg/mL

15 mg/mL

20 mg/mL

30 mg/mL

Amoxicillin

Erythromycin

Gentamycin

Levofloxacin

Tetracycline

(100 μL/well)

B. subtilis

18.2 ± 3.74*

20.3 ± 4.80*

22.1 ± 3.75*

26.1 ± 4.05**

6.5 ± 0.24

20.4 ± 2.45**

7.5 ± 1.55

9.2 ± 2.63

14.1 ± 2.12*

0.00 ± 0.00

E. coli

14.0 ± 3.12

18.2 ± 3.18*

22.5 ± 5.11*

25.2 ± 3.44**

13.4 ± 3.28

17.5 ± 4.50*

14.2 ± 3.25*

13.2 ± 2.52

11.5 ± 2.85

0.00 ± 0.00

K. pneumonia

11.5 ± 2.16

12.4 ± 2.45

15.2 ± 3.31*

17.6 ± 3.70*

5.8 ± 1.42

18.2 ± 4.28*

12.2 ± 2.60

11.2 ± 2.57

10.4 ± 2.44

0.00 ± 0.00

P. aeruginosa

15.1 ± 3.37*

18.1 ± 5.91*

19.7 ± 3.70*

22.6 ± 3.75*

7.0 ± 1.37

17.2 ± 4.78*

10.2 ± 2.26

18.0 ± 4.63*

22.5 ± 5.19*

0.00 ± 0.00

MRSA

14.4 ± 3.41

18.7 ± 4.24*

23.7 ± 6.74**

28.8 ± 5.74**

5.6 ± 1.44

10.4 ± 2.75

6.2 ± 1.71

12.5 ± 2.14*

11.8 ± 2.72

0.00 ± 0.00

S. aureus

18.1 ± 4.94*

22.2 ± 4.16*

23.6 ± 3.52**

27.8 ± 6.92**

8.5 ± 1.74

17.5 ± 4.15*

9.6 ± 2.11

18.2 ± 3.21*

19.2 ± 5.71*

0.00 ± 0.00

S. epidermidis

14.3 ± 3.74*

19.5 ± 4.84*

21.4 ± 3.54*

28.1 ± 5.44**

8.2 ± 2.85

24.0 ± 4.24**

15.2 ± 3.73*

19.5 ± 4.64*

14.2 ± 3.02*

0.00 ± 0.00

S. enterica

15.1 ± 3.32*

19.0 ± 3.53*

23.0 ± 4.25**

27.7 ± 4.36**

6.5 ± 1.87

11.2 ± 2.74

8.3 ± 1.50

24.1 ± 4.32**

9.0 ± 2.27

0.00 ± 0.00

S. fecalis

6.6 ± 3.71

13.9 ± 2.92

15.3 ± 3.47*

17.2 ± 3.29*

7.2 ± 1.74

19.6 ± 4.03*

18.7 ± 4.21*

18.0 ± 4.56*

19.2 ± 3.57*

0.00 ± 0.00

S. pyogenes

13.1 ± 3.32

16.2 ± 4.42*

21.0 ± 3.63**

23.9 ± 3.90**

8.0 ± 2.87

19.0 ± 3.54*

14.2 ± 3.26*

18.7 ± 3.38*

17.5 ± 4.24*

0.00 ± 0.00

S. typhi

10.2 ± 2.16

12.9 ± 2.75

15.1 ± 2.92*

21.1 ± 4.11**

5.2 ± 0.69

11.4 ± 3.24

13.2 ± 3.82*

23.4 ± 4.13**

9.5 ± 2.62

0.00 ± 0.00

  1. Results are mean ± S. D of triplicate experiments
  2. *p ≤ 0.05 significant as compared to control, **p ≤ 0.005 highly significant as compared to control