From: A new indolocarbazole derivative in melanoma and carcinoma lung in vivo treatment
Route of administration | Dose (mg/kg)/ interval (h) x number of administrations | TGI (%) Days post-treatment | ILS (%) | Death of animals (%) | |||||
---|---|---|---|---|---|---|---|---|---|
1 | 4 | 8 | 12 | 16 | 20 | ||||
s.c. | 60/24 × 5 | 78* | 78* | 66* | 61* | 45 | 58* | 34* | 0 |
100/2 × 96 | 80* | 75* | 69* | 64* | 64* | 68* | 15* | 0 | |
120/2 × 96 | 86* | 79* | 72* | 71* | 64* | 63* | 19* | 0 | |
per os | 130/24 × 5 | 64* | 56* | 52* | 31* | 35* | 24 | – | 0 |
150/24 × 5 | 69* | 64* | 61* | 44* | 42* | 43* | 13* | 0 | |
200/24 × 5 | 45* | 56* | 48* | 41* | 28 | 45* | – | 0 | |
i.v. | 60/24 × 5 | 94* | 68* | 57* | 61* | 56* | 51* | 11* | 0 |
70/24 × 5 | 96* | 86* | 80* | 81* | 61* | 77* | 8* | 0 | |
80/24 × 5 | 71* | 76* | 60* | 54* | 39* | 71* | 9* | 0 | |
150 × 1 | 81* | 49* | 24 | 35 | 13 | 27 | – | 0 | |
180 × 1 | – | – | – | – | – | – | – | 86 | |
i.p. | 60/24Ñ…5 | 63* | 60* | 52* | 37 | 39 | 41 | 23* | 0 |
100/2 × 96 | 53* | 53* | 49* | 47* | 36 | 47* | 27* | 0 | |
120/2 × 96 | 61* | 73* | 68* | 61* | 66* | 67* | – | 0 |