Table 6 Pharmacokinetic parameters of VOC-P188 solid dispersion and VOC-β-CD inclusion by oral administration. Values represent the means ± standard error (n = 6)

SA

VOC

630.64 ± 309.58

0.19 ± 0.10

1.31 ± 1.58

3.79 ± 1.40

4.19 ± 0.49

1260.98 ± 273.94

/

VOC-P188

700.75 ± 348.70

0.20 ± 0.16

1.50 ± 1.59

7.24 ± 2.57

6.45 ± 0.96^**

2363.17 ± 350.93^**

185.82

VOC-β-CD

398.92 ± 68.35^#

0.50 ± 0.26^*#

2.34 ± 1.24

2.98 ± 0.57

6.22 ± 1.51^*

1825.75 ± 532.32^#

138.69

NBP

VOC

25.94 ± 8.30

0.47 ± 0.07

0.26 ± 0.10

0.65 ± 0.74

2.70 ± 0.47

36.11 ± 7.58

/

VOC-P188

23.48 ± 1.59

0.32 ± 0.20

2.82 ± 1.55^**

3.13 ± 1.01^*

4.07 ± 0.46^**

72.70 ± 9.80^**

197.67

VOC-β-CD

22.42 ± 5.56

0.83 ± 0.26^**##

3.95 ± 1.96^**

4.39 ± 1.82^**

5.28 ± 1.04^**##

76.06 ± 24.65^**

198.39

NOL

VOC

222.78 ± 71.31

0.18 ± 0.12

0.46 ± 0.67

3.10 ± 2.18

3.42 ± 0.57

442.24 ± 45.19

/

VOC-P188

243.68 ± 130.94

0.42 ± 0.45

4.21 ± 4.29^*

8.84 ± 1.84^**

7.61 ± 0.57^**

1138.94 ± 63.85^**

258.18

VOC-β-CD

134.07 ± 24.28^#

0.67 ± 0.26^*

3.21 ± 2.44

9.77 ± 2.71^**

8.17 ± 0.55^**

944.58 ± 84.96^**##

218.01

ZL

VOC

213.68 ± 76.01

0.22 ± 0.09

0.82 ± 0.51

5.48 ± 2.61

3.94 ± 0.54

503.96 ± 53.33

/

VOC-P188

319.61 ± 285.56

0.49 ± 0.42

4.40 ± 4.10^*

8.91 ± 5.25

5.95 ± 0.49^**

801.47 ± 199.45^**

163.35

VOC-β-CD

145.01 ± 24.76

0.40 ± 0.17

4.72 ± 1.92^*

5.96 ± 2.90

7.31 ± 0.33^**##

883.20 ± 210.53^**

224.54

BP

VOC

43.70 ± 10.89

0.50 ± 0.28

1.38 ± 1.02

3.74 ± 3.26

3.46 ± 1.08

99.09 ± 23.33

/

VOC-P188

40.26 ± 8.37

0.42 ± 0.33

2.72 ± 3.66

8.64 ± 2.44^*

7.42 ± 0.60^**

249.21 ± 24.50^**

251.50

VOC-β-CD

38.80 ± 15.96

0.35 ± 0.19

7.02 ± 5.42^*

19.57 ± 5.63^**##

8.45 ± 0.77^**

298.49 ± 31.68^**##

363.55