Pharmacokinetics of five phthalides in volatile oil of Ligusticum sinense Oliv.cv. Chaxiong, and comparison study on physicochemistry and pharmacokinetics after being formulated into solid dispersion and inclusion compound

Table 5 Pharmacokinetic parameters of VOC by oral and intravenous administration. Values represent the means ± standard error (n = 6)

components	Group	C_max (μg/l)	T_max (h)	t_1/2α (h)	t_1/2β (h)	MRT_0-t (h)	AUC_0-t (μg/l*h)	F₁(%)
SA	iv	3425.09 ± 556.79	0.083 ± 0.00	0.09 ± 0.05	0.78 ± 0.66	0.72 ± 0.08	1370.79 ± 314.70	/
SA	po	630.64 ± 309.58	0.19 ± 0.10	1.31 ± 1.58	3.79 ± 1.40	4.19 ± 0.49	1260.98 ± 273.94	22.30
NBP	iv	196.44 ± 64.48	0.083 ± 0.00	0.06 ± 0.04	0.26 ± 0.15	0.54 ± 0.22	54.64 ± 16.50	/
NBP	po	25.94 ± 8.30	0.47 ± 0.07	0.26 ± 0.10	0.65 ± 0.74	2.70 ± 0.47	36.11 ± 7.58	16.32
NOL	iv	1381.81 ± 334.90	0.083 ± 0.00	0.04 ± 0.04	0.30 ± 0.11	0.79 ± 0.17	504.65 ± 152.08	/
NOL	po	222.78 ± 71.31	0.18 ± 0.12	0.46 ± 0.67	3.10 ± 2.18	3.42 ± 0.57	442.24 ± 45.19	21.90
ZL	iv	4531.32 ± 1447.37	0.083 ± 0.00	0.04 ± 0.04	0.55 ± 0.66	0.45 ± 0.10	1239.94 ± 434.83	/
ZL	po	213.68 ± 76.01	0.22 ± 0.09	0.82 ± 0.51	5.48 ± 2.61	3.94 ± 0.54	503.96 ± 53.33	10.16
BP	iv	373.30 ± 155.03	0.083 ± 0.00	0.04 ± 0.04	0.70 ± 0.54	1.28 ± 0.32	198.46 ± 42.81	/
BP	po	43.70 ± 10.89	0.50 ± 0.28	1.38 ± 1.02	3.74 ± 3.26	3.46 ± 1.08	99.09 ± 23.33	12.43

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