Table 4 Anti-leishmanial activity and selectivity indexes of isolated compounds against L. donovani promastigotes and amastigotes
From: Bio-guided isolation of anti-leishmanial natural products from Diospyros gracilescens L. (Ebenaceae)
Compound | IC50 (Promastigotes) (μM ± SD) | IC50 (Amastigotes) (μM ± SD) | Raw267.4 CC50 (μM ± SD) | SI (Promastigotes) | SI (Amastigotes) |
|---|---|---|---|---|---|
Lupeol (1) from fraction A | 23.22 ± 0.08 | 46.66 ± 0.65 | 19.28 ± 0.3 | 0.82 | 0.41 |
Betulin (2) from fraction B | NT | NT | ND | ND | ND |
Betulinic acid (3) from fraction B | 13.69 ± 0.07 | 18.46 ± 0.01 | 82.39 ± 0.09 | 6.02 | 4.46 |
Mixture of sterols (4) from fraction A | 46.83 ± 0.20 | 17.83 ± 0.17 | 18.26 ± 0.18 | 0.39 | 1.02 |
β-sitosterol glucoside (6) from fraction D | 49.34 ± 0.12 | 32 ± 0.22 | 28.60 ± 0.07 | 0.58 | 0.89 |
1-deoxyinositol (7) from fraction D | 241.71 ± 0.16 | 120 ± 0.18 | >  1218 ± 0.13 | > 5.04 | > 10.15 |
Amphotericin B | 0.37 ± 0.22 | 0.13 ± 0.11 |  | / | / |