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Table 4 Anti-leishmanial activity and selectivity indexes of isolated compounds against L. donovani promastigotes and amastigotes

From: Bio-guided isolation of anti-leishmanial natural products from Diospyros gracilescens L. (Ebenaceae)

Compound IC50
(Promastigotes) (μM ± SD)
IC50
(Amastigotes)
(μM ± SD)
Raw267.4 CC50
(μM ± SD)
SI (Promastigotes) SI (Amastigotes)
Lupeol (1) from fraction A 23.22 ± 0.08 46.66 ± 0.65 19.28 ± 0.3 0.82 0.41
Betulin (2) from fraction B NT NT ND ND ND
Betulinic acid (3) from fraction B 13.69 ± 0.07 18.46 ± 0.01 82.39 ± 0.09 6.02 4.46
Mixture of sterols (4) from fraction A 46.83 ± 0.20 17.83 ± 0.17 18.26 ± 0.18 0.39 1.02
β-sitosterol glucoside (6) from fraction D 49.34 ± 0.12 32 ± 0.22 28.60 ± 0.07 0.58 0.89
1-deoxyinositol (7) from fraction D 241.71 ± 0.16 120 ± 0.18 >  1218 ± 0.13 > 5.04 > 10.15
Amphotericin B 0.37 ± 0.22 0.13 ± 0.11   / /
  1. Activity data are expressed as mean ± Standard deviation (SD) from triplicate experiments; IC50: 50% Inhibitory Concentration, ND: Non-Determined; NT: Non-Tested (Betulin not tested due to insufficient quantity)