From: Bio-guided isolation of anti-leishmanial natural products from Diospyros gracilescens L. (Ebenaceae)
Extract/ fraction | IC50 (Promastigotes) (μg/ml ± SD) | IC50 (Amastigotes) (μg/ml) ± SD | Raw267.4 CC50 (μg/ml ± SD) | SI (Promastigotes) | SI (Amastigotes) |
---|---|---|---|---|---|
Trunk crude extract | 5.84 ± 0.20f | 35.69 ± 0.26f | >  100 | >  18.56 | >  2.80 |
Hexane fraction (A) | 0.79 ± 0.09b | 8.06 ± 0.39b | >  100 | >  126.74 | >  12.40 |
Dichloromethane fraction (B) | 1.63 ± 0.11d | 10.97 ± 0.11c | >  100 | >  61.16 | >  9.11 |
Ethyl-acetate fraction (C) | 2.36 ± 0.06e | 16.05 ± 0.12d | >  100 | >  42.30 | >  6.23 |
n-butanol fraction (D) | 1.11 ± 0.10c | 22.08 ± 0.09e | >  100 | >  89.60 | >  4.53 |
Water residue (E) | >  100 | – | – | – | – |
Positive control | 0.34 ± 0.22a | 0.12 ± 0.11a | / | / | / |