From: Acupuncture for post-stroke depression: a systematic review and meta-analysis
Source | Reference No. | Intervention | Sample Size (T/C), Dropout (T/C) | Age (T/C) | Depression Definition | Duration | Outcome (s) | Adverse events | Overall quality for each trial | |
---|---|---|---|---|---|---|---|---|---|---|
Treatment | Control | |||||||||
Acupuncture/EA + conventional treatment a vs. conventional treatment | ||||||||||
Guo 2009 | [26] | Acupuncture (SP4, PC6, SJ5, GB41, SI3, BL62, LU7, KI6, 30 min/d) + psychological counselling+ physical rehabilitation | Sertraline (50 mg/d) + psychological counselling + physical rehabilitation | 40/40 | 65.8 ± 9.61/67.6 ± 12.43 | HAM-D17 ≥ 8 | 30 d | HAM-D17 | NR | Moderate quality |
Guo 2012 | [28] | Acupuncture (PC6, GV 20, GV29, LR3, HT7, BL15, SP6, KI3, ST36, EX-HN1, ST40, 30 min/d) + physical rehabilitation | physical rehabilitation | 55/55 | 60.30 ± 4.80/60.80 ± 3.90 | HAM-D17 ≥ 8 | 30 d | HAM-D17 | NR | Moderate quality |
Zhang 2019 | [17] | Acupuncture (LI4, ST40, ST16, HT7, SP6, LR3, PC6, EX-HN1, GV29, GV24, GV20, 40 min/d) + Fluoxetine (20 mg/d) | Fluoxetine (20 mg/d) | 48/48 | 57.2 ± 8.5/58.5 ± 7.8 | HAM-D ≥ 20 | 6 m | HAM-D scores | T: 2 cases of skin redness and swelling, 1 case of constipation. C: 1 case of constipation, 1 case of abdominal distension. | Moderate quality |
Sun 2015 | [35] | Acupuncture (GV 20, GV16, GV 24, GV 26, GV14, GV 11, 40 min/d) + Fluoxetine (20 mg/d) | Fluoxetine (20 mg/d) | 33/30 | 59 ± 7/51 ± 6 | HAM-D24 ≥ 8 | 4 w | HAM-D24 | NR | Moderate quality |
Chen 2018 | [16] | Acupuncture (PC6, GV20, LI4, KI3, LR3, HT7, BL15, SP6, KI3, ST36, EX-HN1, ST10, 30 min/d) + conventional drug therapy | Conventional drug therapy | 30/30 | 57 ± 11/58 ± 11 | HAM-D24 ≥ 24 | 4 w | HAM-D24 | None | Moderate quality |
Jiang 2007 | [23] | EA (GV20, EX-HN3, sparse-dense waves 2/100 Hz, tolerable strength, 30 min/d) + Fluoxetine (20 mg/d) | Fluoxetine (20 mg/d) | 31/30, 3/2 | 60.32 ± 3.26/61. 18 ± 2.94 | HAM-D scores ≥8 | 28 d | HAM-D scores | None | Moderate quality |
Sun Y b 2015 | [37] | EA (the midnight-noon ebb-flow theory, continuous wave, 2 Hz, 30 min/d) + Fluoxetine (20 mg/d) | Fluoxetine (20 mg/d) | 31/31 | 67 ± 4/69 ± 5 | HAM-D17 ≥ 17 | 6 m | HAM-D17 | T: 1 case of dry mouth, 1 case of fatigue. C: 2 cases of intermittent headache, 2 cases of loss of appetite, 2 cases of nausea. | High quality |
Acupuncture/EA (+placebo) vs. antidepressants (+sham acupuncture) | ||||||||||
Zhou 2012 | [24] | Acupuncture (GV20, Ex-HN1, LR3, ST36, SP6, 20 min/d) | Fluoxetine (20 mg/d) | 30/30, 2/2 | 65.34 ± 10.60/ 66.03 ± 9.51 | HAM-D24 ≥ 8 | 30 d | HAM-D24 | NR | Low quality |
Sun 2013 | [27] | Acupuncture (GV20, GV16, GV24, GV26, GV14, GV11, 40 min/d) | Fluoxetine (20 mg/d) | 30/30 | 58 ± 8/59 ± 9 | HAM-D24 ≥ 20 | 4 w | HAM-D24 | NR | Moderate quality |
Ding 2003 | [29] | Acupuncture (GV20, DU24, DU16, 30 min/d) | Fluoxetine (20 mg/d) | 30/30,1/1 | NR | HAM-D score ≥ 20 | 60 d | HAM-D score | C: 3 cases of mild abdominal pain, 2 cases of mild nausea and vomiting, 3 cases of elevated GOT and GPT. | Moderate quality |
Li 2011 | [30] | Acupuncture (GV20, Ex-HN1, LR3, Ex-HN3, 30 min/d) + oral placebo | Non-acupoint spots+ Fluoxetine (20 mg/d) | 23/20,1/2 | 29–90/32–63 | HAM-D17 ≥ 17 | 6 w | HAM-D17 | T: 1 case of pain, 1 case of dizziness and nausea and 1 case of haematoma. C: 1 case of dizziness, 1 case of numbness, 1 case of palpitation. | High quality |
Liu 2006 | [32] | Acupuncture (Ex-HN1, PC6, HT7, ST36, SP6, KI6, LR3, BL62, 30 min/d) | Fluoxetine (20 mg/d) | 101/145 | 60.0 ± 9.8/59.6 ± 8.9 | HAM-D scores ≥8 | 6 w | HAM-D score | NR | Moderate quality |
Qian 2015 | [33] | Acupuncture (GV26, PC6, HT7, ST36, 30 min/d) + placebo | Fluoxetine (20 mg/d) + Shallow puncture | 32/33,2/1 | 67.59 ± 11.02/67.74 ± 8.61 | HAM-D17 ≥ 17 | 6 w | HAM-D17 | T: 2 cases of needle sticks, 1 case of bent needles, 2 cases of haematomas. C: 1 case of haematomas. | High quality |
Zhang 2016 | [34] | Acupuncture (GV26, GV24, GV15, BL18, BL23, LR3, KI3, PC6, HT7, CV17, 15 min/d) | Escitalopram Oxalate tablet (1.25–10 mg/d) | 33/32,2/3 | 58.0 ± 5.3/59.0 ± 4.5 | HAM-D17 ≥ 18 | 8 w | HAM-D17 | C: 2 cases of dizziness, 2 cases of nausea and 1 case of tolerable joint pain | Moderate quality |
Zhou 2016 | [36] | Acupuncture (GV20, EX-HN1, HT7, SP6, PC6, GV24, 30 min/d) | Doxepin hydrochloride tablets | 58/58 | 59.45 ± 9.03/58.16 ± 8.14 | HAM-D scores ≥17 | 4 w | HAM-D scores | None | Low quality |
Li 2015 | [25] | EA (LI4, LR3, continuous waves 2 Hz, 20 min/d) | Fluoxetine (20 mg/d) | 11/10 | 62.56 ± 6.85, 66.42 ± 6.25 | HAM-D17 ≥ 18 | 8 w | HAM-D17 | NR | Moderate quality |
Chu 2007 | [31] | EA (GV20, DU26, GV29, PC6, sparse-dense waves 6–8 Hz, 30 min/d) | Fluoxetine (20 mg/d) | 36/36 | 54–78/58–72 | HAM-D scores ≥8 | 8 w | HAM-D scores | C:3 cases of dry mouth, 3 cases of dizziness, 2 cases of drowsiness. | Moderate quality |
Sun Y b 2015 | [37] | EA (the midnight-noon ebb-flow theory, continuous wave, 2 Hz, 30 min/d) | Fluoxetine (20 mg/d) | 31/31 | 67 ± 4/69 ± 5 | HAM-D17 ≥ 17 | 6 m | HAM-D17 | C: 2 cases of intermittent headache, 2 cases of loss of appetite, 2 cases of nausea. | High quality |