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Table 4 Histopathological NAS

From: Hepatoprotective effect of silymarin on fructose induced nonalcoholic fatty liver disease in male albino wistar rats

NAFLD Activity Score

GROUPS

NC

FC

SC

FTH

FFH

Steatosis grade

0

0.83*

0.17

0.50

0.33

Location of steatosis)

0

0.50

0

0

0

Microvesicular steatosis

0

0.17

0

0

0

Lobular inflammation

0

0.17

0

0

0

Fibrosis stage

0

0

0

0

0

Microgranulomas

0

0

0

0

0

Large lipogranulomas

0

0

0

0

0

Portal inflammation

0

0

0

0

0

Liver cell injury (ballooning)

0

0.17

0

0

0

Acidophil bodies

0

0

0

0

0

Pigmented microphages

0

0

0

0

0

Mega mitochondria

0

0

0

0

0

Mallory’s hyaline

0

0

0

0

0

Glycogenated nuclei

0

0

0

0

0

Total sum

0

1.84

0.17

0.50

0.33

Diagnostic classification for NASH

Not steatosis

Possible/border line

Not steatosis

Not steatosis

Not steatosis

  1. Histopathological NAS. NC normal control, FC fructose control, SC silymarin control, FTH fructose + 200 mg/kg silymarin, FFH fructose + 400 mg/kg silymarin. Values are mean (n = 6) for each group. * p < 0.05 vs. NC