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Table 4 Histopathological NAS

From: Hepatoprotective effect of silymarin on fructose induced nonalcoholic fatty liver disease in male albino wistar rats

NAFLD Activity Score GROUPS
NC FC SC FTH FFH
Steatosis grade 0 0.83* 0.17 0.50 0.33
Location of steatosis) 0 0.50 0 0 0
Microvesicular steatosis 0 0.17 0 0 0
Lobular inflammation 0 0.17 0 0 0
Fibrosis stage 0 0 0 0 0
Microgranulomas 0 0 0 0 0
Large lipogranulomas 0 0 0 0 0
Portal inflammation 0 0 0 0 0
Liver cell injury (ballooning) 0 0.17 0 0 0
Acidophil bodies 0 0 0 0 0
Pigmented microphages 0 0 0 0 0
Mega mitochondria 0 0 0 0 0
Mallory’s hyaline 0 0 0 0 0
Glycogenated nuclei 0 0 0 0 0
Total sum 0 1.84 0.17 0.50 0.33
Diagnostic classification for NASH Not steatosis Possible/border line Not steatosis Not steatosis Not steatosis
  1. Histopathological NAS. NC normal control, FC fructose control, SC silymarin control, FTH fructose + 200 mg/kg silymarin, FFH fructose + 400 mg/kg silymarin. Values are mean (n = 6) for each group. * p < 0.05 vs. NC
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