Table 2 Skin conditions after MCM patch treatment during 7 days in DNCB-induced AD mice

Barrier Score

NC

80.1 ± 7.3 ^***

69.4 ± 6.9 ^***

74.6 ± 6.9 ^***

DNCB Only

63.7 ± 5.9

55.9 ± 5

53.8 ± 12.2

PC

60.1 ± 4.5

57.3 ± 8.2

57.2 ± 7.8

MCM

65.8 ± 2.3

64.7 ± 4.2 ^*

63.5 ± 7 ^*

Barrier Strength

NC

83.8 ± 2.9 ^***

76 ± 4.1^***

85.8 ± 3.4 ^***

DNCB Only

65.1 ± 9.5

53.6 ± 6.7

51.5 ± 22.9

PC

63 ± 5.4

64.5 ± 6.7^*

63.2 ± 7.8^*

MCM

76.9 ± 4.5 ^*

75 ± 6.4^***

72.8 ± 7.3 ^***

Moisture Level

NC

77.1 ± 12.8 ^***

61.6 ± 11.4^**

59.6 ± 11.6

DNCB Only

54.4 ± 5

50.2 ± 0.4

52.8 ± 5.7

PC

50.2 ± 0.4

54.9 ± 10.3

50.3 ± 0.5

MCM

50.3 ± 0.5

51.3 ± 3.2

55.7 ± 9

Transepidermal Water Loss

NC

7.3 ± 1.6^***

10.5 ± 2.07^***

6.4 ± 1.9^***

DNCB Only

15.9 ± 5.2

22.4 ± 3.3

22.2 ± 11.5

PC

17.2 ± 3.2

19.6 ± 8.3

18.5 ± 3.4

MCM

10.7 ± 2.1

11.1 ± 2.9^***

12.8 ± 3.7^***