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Table 2 Skin conditions after MCM patch treatment during 7 days in DNCB-induced AD mice

From: Effects of mineral complex material treatment on 2,4- dinitrochlorobenzene-induced atopic dermatitis like-skin lesions in mice model

Parameters Groups Treatment Days 3 7
1
Barrier Score NC 80.1 ± 7.3 *** 69.4 ± 6.9 *** 74.6 ± 6.9 ***
DNCB Only 63.7 ± 5.9 55.9 ± 5 53.8 ± 12.2
PC 60.1 ± 4.5 57.3 ± 8.2 57.2 ± 7.8
MCM 65.8 ± 2.3 64.7 ± 4.2 * 63.5 ± 7 *
Barrier Strength NC 83.8 ± 2.9 *** 76 ± 4.1*** 85.8 ± 3.4 ***
DNCB Only 65.1 ± 9.5 53.6 ± 6.7 51.5 ± 22.9
PC 63 ± 5.4 64.5 ± 6.7* 63.2 ± 7.8*
MCM 76.9 ± 4.5 * 75 ± 6.4*** 72.8 ± 7.3 ***
Moisture Level NC 77.1 ± 12.8 *** 61.6 ± 11.4** 59.6 ± 11.6
DNCB Only 54.4 ± 5 50.2 ± 0.4 52.8 ± 5.7
PC 50.2 ± 0.4 54.9 ± 10.3 50.3 ± 0.5
MCM 50.3 ± 0.5 51.3 ± 3.2 55.7 ± 9
Transepidermal Water Loss NC 7.3 ± 1.6*** 10.5 ± 2.07*** 6.4 ± 1.9***
DNCB Only 15.9 ± 5.2 22.4 ± 3.3 22.2 ± 11.5
PC 17.2 ± 3.2 19.6 ± 8.3 18.5 ± 3.4
MCM 10.7 ± 2.1 11.1 ± 2.9*** 12.8 ± 3.7***
  1. NC Normal control group without any treatment, DNCB only Negative control group treated with DNCB only, PC Positive control group treated with DNCB and tacrolimus ointment, and MCM Experimental group treated with DNCB and MCM patch. Data are expressed as mean ± SD for 8 mice. Significance difference was analyzed with ANOVA and Tukey’s test. *p < 0.05, **p < 0.01, *** p < 0.001 vs. DNCB only group