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Table 2 RUCAM for liver injury

From: Case series and review of Ayurvedic medication induced liver injury

  Possible
Score
Patient
1
Patient
2
Patient
3
Time to onset + 2 + 2 + 1 + 2
 5–90 days     
  < 5 or > 90 days + 1    
Course of ALT after cessation of herb   + 2 + 3 + 2
 Decrease > 50% within 8 days + 3    
 Decrease > 50% within 30 days + 2    
Risk factors
 Alcohol + −1    
 Alcohol - 0 0 0 0
 Age > 55 years + 1 + 1   
 Age < 55 years 0   0 0
No concomitant drugs/herbs   0 0 0
All causes-group I and II-ruled out   + 2 + 2 + 2
Previous hepatotoxicity   + 1 + 1 + 1
 Reaction labeled in the product characteristics + 2    
 Reaction published but not labeled + 1    
Response to unintentional re-exposure   0 0 0
Total score for the case   + 8 + 7 + 7
  1. RUCAM score causality levels < 0 excluded causality; 1–2 unlikely; 3–5, possible; 6–8, probable; and > 9, highly probable (ref [26])