Essential oils from Syzygium aromaticum and Zingiber officinale, administered alone or in combination with benznidazole, reduce the parasite load in mice orally inoculated with Trypanosoma cruzi II

Table 1 Statistical comparisons of parasitological parameters and cure rates in mice inoculated with Trypanosoma cruzi (Y strain - TcII), treated with 100 mg/kg/day of benznidazole (BZ), the essential oil of Syzygium aromaticum (CEO) or the combination of the two (BZ + CEO) for 20 consecutive days, and in untreated controls (NT)

Parameters	NT	BZ	CEO	BZ + CEO	p-value^*
%INF^a	100.0	100.0	100.0	100.0	NS^b
PP (days)^c	6.9 ± 1.6^#	0.0^&	8.6 ± 1.1^#	0.0^&	< 0.0001
Pmax^d	153,792.0 ± 40,208.0^#	0.0^&	111,656.0 ± 18,201.1^#	0.0^&	< 0.0001
Dpmax^e	16.3 ± 2.1^#	0.0^&	14.2 ± 1.3^#	0.0^&	< 0.0001
%MORT^f	42.9 (6/14)	0.0 (0/15)	66.7 (10/15)	0.0 (0/15)	NS
% of cure	_	0.0 (0/15)	0.0 (0/15)	0.0 (0/15)	NS

^a infectivity rate; ^b not significant; ^c mean patent period; ^d maximum of parasitemia (number of trypomastigotes in 0.1 mL of blood); ^e day of maximum peak; ^f mortality rate. Different symbols (^# and ^&) on the same line represent significant differences. Chi-square test for the analysis of proportions and the Mann-Whitney or Kruskall-Wallis tests for analysis of the means. * Values of p ≤ 0.05 were considered significant

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