Fig. 8
From: Porcine placenta extract improves high-glucose-induced angiogenesis impairment
A schematic of stimulatory effect of PPE on HG-induced ROS-mediated angiogenesis impairment. PPE ameliorated HG-induced ROS-mediated ECs viable, migrative, and angiogenesis impairment by showing recovery of PI3K/Akt/ERK1/2 activation. Additionally, PPE also attenuated HG-induced ROS-mediated ECs apoptosis by showing p53/Bax/Caspase9/Caspase3 inhibition