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Table 4 List of the top 20 down-regulated DEGs (DSEH group vs. Blank group)

From: The enzymatic hydrolysates from deer sinew promote MC3T3-E1 cell proliferation and extracellular matrix synthesis by regulating multiple functional genes

Gene name

Blank (FPKM)

DSEH (FPKM)

log2 fold change (DSEH /Blank)

P value

Metallothionein-1 (Mt1)

419.48

188.65

−1.15

6.40E-107

Non-histone chromosomal protein HMG-17 (Hmgn2)

310.59

145.14

−1.10

4.58E-176

Prolactin-2C2 (Prl2c2)

302.57

105.30

−1.52

9.84E-167

Cell division cycle protein 20 homolog (Cdc20)

118.90

57.15

−1.06

3.10E-94

Prolactin-2C3 (Prl2c3)

166.68

55.41

−1.59

1.69E-109

Transmembrane glycoprotein NMB (Gpnmb)

76.68

30.90

−1.31

1.28E-184

Neuropilin-2 (Nrp2)

45.13

22.36

−1.01

2.48E-107

Muscleblind-like protein 1 (Mbnl1)

58.40

19.94

−1.55

6.30E-240

Growth arrest-specific protein 1 (Gas1)

48.10

17.13

−1.49

5.60E-116

Protein PRRC2C (Prrc2c)

31.70

15.05

−1.07

1.73E-153

Monofunctional C1-tetrahydrofolate synthase, mitochondrial (Mthfd1l)

30.62

14.72

−1.06

6.77E-53

Sodium/potassium/calcium exchanger 3 (Slc24a3)

29.19

14.47

−1.01

7.42E-50

Protein DEK (Dek)

29.00

13.78

−1.07

5.39E-36

Semaphorin-3A (Sema3a)

27.29

13.47

−1.02

4.21E-85

High mobility group protein HMGI-C (Hmga2)

34.31

13.10

−1.39

1.50E-35

Mannose-P-dolichol utilization defect 1 protein (Mpdu1)

25.49

12.73

−1.00

1.24E-14

Lymphocyte-specific helicase (Hells)

25.43

11.80

−1.11

7.89E-39

CKLF-like MARVEL transmembrane domain-containing protein 3 (Cmtm3)

30.93

11.47

−1.43

5.24E-36

Homeobox protein engrailed-1 (En1)

32.58

11.37

−1.52

1.05E-65

Small subunit processome component 20 homolog (Utp20)

27.90

11.06

−1.33

1.98E-163