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Table 8 Inhibitory effect of 90% ethanolic extract of C. spectabilis DC leaf on the heme polymerization compared with controls

From: Antiplasmodial activity of Ethanolic extract of Cassia spectabilis DC leaf and its inhibition effect in Heme detoxification

Samples Concentration (mg/ml) Level of hematin (mM) Inhibition (%) IC50 (mg/ml)
90% ethanolic extract of C. spectabilis DC leaf 2 67.32 ± 4.49 76.49 ± 1.57 0.375
1 85.34 ± 1.42 70.20 ± 0.50
0.5 118.49 ± 2.92 58.62 ± 1.02
0.25 186.37 ± 6.55 34.91 ± 2.29
0.1 223.85 ± 4.35 21.82 ± 1.52
0.01 252.00 ± 1.85 11.99 ± 0.64
Chloroquine diphosphate 2 99.80 ± 2.50 65.15 ± 0.97 0.682
1 125.65 ± 4.03 56.12 ± 1.41
0.5 158.00 ± 4.63 44.82 ± 1.62
0.25 186.78 ± 3.95 34.76 ± 1.38
0.1 207.05 ± 1.96 27.69 ± 0.68
0.01 229.53 ± 9.26 19.84 ± 3.24
DMSO 286.33 ± 2.92
  1. DMSO were used as a negative control