Table 8 Inhibitory effect of 90% ethanolic extract of C. spectabilis DC leaf on the heme polymerization compared with controls
Samples | Concentration (mg/ml) | Level of hematin (mM) | Inhibition (%) | IC50 (mg/ml) |
|---|---|---|---|---|
90% ethanolic extract of C. spectabilis DC leaf | 2 | 67.32 ± 4.49 | 76.49 ± 1.57 | 0.375 |
1 | 85.34 ± 1.42 | 70.20 ± 0.50 | ||
0.5 | 118.49 ± 2.92 | 58.62 ± 1.02 | ||
0.25 | 186.37 ± 6.55 | 34.91 ± 2.29 | ||
0.1 | 223.85 ± 4.35 | 21.82 ± 1.52 | ||
0.01 | 252.00 ± 1.85 | 11.99 ± 0.64 | ||
Chloroquine diphosphate | 2 | 99.80 ± 2.50 | 65.15 ± 0.97 | 0.682 |
1 | 125.65 ± 4.03 | 56.12 ± 1.41 | ||
0.5 | 158.00 ± 4.63 | 44.82 ± 1.62 | ||
0.25 | 186.78 ± 3.95 | 34.76 ± 1.38 | ||
0.1 | 207.05 ± 1.96 | 27.69 ± 0.68 | ||
0.01 | 229.53 ± 9.26 | 19.84 ± 3.24 | ||
DMSO | – | 286.33 ± 2.92 | – | – |