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Table 5 Stage-specific activity of 90% ethanolic extracts of C. spectabilis DC leaf against P. falciparum 3D7 strain

From: Antiplasmodial activity of Ethanolic extract of Cassia spectabilis DC leaf and its inhibition effect in Heme detoxification

Samples Incubation time (hours) Parasitic stage % parasitemia % growth % inhibition
Ring Trophozoite Schizont
Negative control 0 41 5 1 0.76
6 38 11 2 0.84 0.08
12 36 15 2 0.86 0.10
24 45 19 7 1.14 0.38
48 95 30 4 2.06 1.30
90% ethanolic extract of C. spectabilis DC leaf 0 41 5 1 0.76
6 38 10 1 0.81 0.05 37.5
12 34 11 5 0.79 0.03 70
24 22 13 2 0.59 0 100
48 17 0 0 0.28 0 100
  1. % parasitemia was obtained from total number of parasites divide to ring, trophozoite and schizont
  2. % growth was obtained from % parasitemia an incubation time minus % parasitemia at 0 h
  3. % inhibition was calculated according to the following formula: % inhibition = ((parasitemia in negative control – parasitemia in treatment group) / parasitemia in negative control) × 100
  4. Negative control: The cultures were only added with DMSO, without any extract. The DMSO was used as negative control because DMSO was used to dissolve the extract