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Table 1 Blood pressure changes after induction of hypertension with 66% w/v D-fructose in rats

From: Methanol (80%) leaf extract of Otostegia integrifolia Benth (Lamiaceae) lowers blood pressure in rats through interference with calcium conductance

BP

Group

BP Measurement Period

Day 0

Day 5

Day 10

Day 15

SBP

NCR

112.75 +  3.99

109.50 +  4.31

101.16 + 7.2

111.41 + 0.96

DF66

118.66 +  4.8

185.16 +  6.68***

161 + 9.25 ***

151.58 + 4.02***

DBP

NCR

69.00 + 6.91

84.00 + 5.49

80.37 + 6.95

78.79 +  3.43

DF66

89.66 + 5.03

164.54 + 6.69***

144.62 + 10.84***

143.58 + 4.02***

MAP

NCR

83.58 + 3.80

92.50 + 4.92

87.41 + 7.07

89.66 +  2.41

DF66

99.33 + 4.51

171.41 + 6.41***

150.25 + 10.26***

142.91 + 4.88***

NCR

43.75 + 10.12

16.87 +  2.64

33.62 + 5.2

22.00 + 1.95

PP

DF66

25.50 + 3.05

14.00 + 4.11

18.32 + 1.52*

22.00 + 2.35

  1. Data are expressed as mean ± SEM (n = 6); Analysis was performed by one-way ANOVA; SBP Systolic blood pressure, DBP Diastolic blood pressure, MAP Mean arterial pressure, PP Pulse pressure, NCR Normal control rats without fructose ingestion, DF66 Rats with 66% fructose ingestion; *p < 0.05; ***p < 0.001.