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Table 3 Changes in DASS-21 and SF-36 scores over time

From: Efficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study

    Baseline Week 4 Week 8 Repeated Measures ANOVA Cohen’s D effect size
p-value time effects p-value time x group interaction
DASS-21: Total Score Placebo (n = 39) Mean 22.87 19.71 19.28 .058 .044 .46
SE 2.71 2.69 3.03
Curcumin (n = 38) Mean 23.42 13.95 13.89 <.001
SE 3.16 1.81 1.86
DASS-21: Depression Placebo (n = 39) Mean 6.31 5.33 5.44 .423 .363 .26
SE 1.03 1.00 1.15
Curcumin (n = 38) Mean 5.79 3.42 3.47 .006
SE 1.25 0.72 0.64
DASS-21: Anxiety Placebo (n = 39) Mean 5.08 4.67 4.26 .375 .023 .53
SE 0.85 0.86 0.83
Curcumin (n = 38) Mean 5.68 3.05 2.74 <.001
SE 0.90 0.57 0.59
DASS-21: Stress Placebo (n = 39) Mean 11.49 9.18 9.59 .007 .157 .35
SE 1.22 1.16 1.30
Curcumin (n = 38) Mean 11.95 7.47 7.68 <.001
SE 1.45 0.82 0.95
SF-36: Physical functioning Placebo (n = 39) Mean 88.08 89.74 91.92 .170 .250 .11
SE 2.31 2.77 2.60
Curcumin (n = 38) Mean 86.58 90.92 89.08 .019
SE 2.45 1.70 2.32
SF-36: Role limitations due to physical health Placebo (n = 39) Mean 69.87 80.13 84.87 .137 .814 .03
SE 6.37 5.60 4.77
Curcumin (n = 38) Mean 69.74 84.87 81.41 .008
SE 6.68 2.32 5.09
SF-36: Role limitations due to emotional problems Placebo (n = 39) Mean 59.79 66.67 77.79 .019 .476 .14
SE 6.03 6.13 5.53
Curcumin (n = 38) Mean 70.24 81.61 82.45 .060
SE 5.74 4.82 5.00
SF-36: Energy/fatigue Placebo (n = 39) Mean 41.79 46.92 52.05 .003 .073 .11
SE 3.55 3.26 3.59
Curcumin (n = 38) Mean 44.47 56.58 52.63 <.001
SE 2.93 2.80 3.48
SF-36: Emotional wellbeing Placebo (n = 39) Mean 67.90 71.69 79.47 .016 .272 .20
SE 2.39 2.93 2.06
Curcumin (n = 38) Mean 73.47 79.47 74.26 .047
SE 2.59 2.06 2.58
SF-36: Social functioning Placebo (n = 39) Mean 74.87 85.13 89.92 <.001 .983 .01
SE 3.88 3.00 2.81
Curcumin (n = 38) Mean 74.18 85.05 88.97 <.001
SE 3.27 3.50 2.60
SF-36: General health Placebo (n = 39) Mean 58.72 63.59 65.26 .002 .919 .08
SE 3.83 3.33 3.38
Curcumin (n = 38) Mean 65.13 69.47 70.53 .031
SE 2.86 2.77 3.13
SF-36 - Pain Placebo (n = 39) Mean 74.41 79.15 81.51 .018 .023 .43
SE 3.06 2.82 2.54
Curcumin (n = 38) Mean 62.66 77.61 77.29 <.001
SE 3.49 2.78 2.99