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Fig. 4 | BMC Complementary Medicine and Therapies

Fig. 4

From: Panax notoginseng saponins promote endothelial progenitor cell angiogenesis via the Wnt/β-catenin pathway

Fig. 4

Treatment with PNS rescued tube formation and migration of EPCs transfected by shRNA-β-catenin. a EPCs were treated with 6.25 mg/L PNS and incubated for 72 h. The mRNA expression of VEGF, bFGF and VE-cadherin was detected by qRT-PCR. b-c Silencing of β-catenin inhibits the angiogenesis ability of EPCs, while PNS could reverse the ability in vitro. **p < 0.01, *p < 0.05 v.s. CTRL group, ##p < 0.01 v.s. shRNA-β-catenin group. d-e Migration assay was conducted in EPCs with indicated treatment. The migration cell number was measured at 72 h after the cells had been treated. ***p < 0.001, *p < 0.05 v.s. CTRL group, #p < 0.05 v.s. shRNA-β-catenin group

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