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Table 4 The predicted targets of partly components of Danshen and Siwu decoction. Danshen

From: Comparative study of Danshen and Siwu decoction based on the molecular structures of the components and predicted targets

Target Compoud Disease Source
Acetylcholinesterase Tanshinaldehyde Alzheimer’s disease Danshen
Aldose reductase Rosmarinic acid diabetes mellitus Danshen
Bcl-2-related protein EAT/mcl1 Neotanshinone A leucocythemia Danshen
Bile acid receptor przewalskin A cardiovascular disease, liver disease Danshen
Carbonic anhydrase 2 Protocatechuic acid tumour Danshen
Cocaine esterase Tanshinone II A Sodium Sulfonate detoxification of xenobiotics and in the activation of ester and amide prodrugs Danshen
Carbonic anhydrase 3-lactamide tumor Danshen
DNA topoisomerase 2 Trijuganone A tumor Danshen
M18 aspartyl aminopeptidase Prolithospermic acid parasitic disease Danshen
Sex hormone-binding globulin przewalskin B diabetes mellitus Danshen
TrpV4 3-Oxoisotaxodione cardiovascular disease Danshen
Adenosine receptor A1 Adenosine central nervous system disease Siwu decoction
Alpha-glucosidase, Glucoamylase paeonin hyperglycemia Siwu decoction
Carbonic anhydrase 9 East terpene lactone tumor Siwu decoction
Cathepsin B Leucine tumor Siwu decoction
Epidermal growth factor receptor Vanillin tumor Siwu decoction
Integrin beta-1 Tyrosine tumor Siwu decoction
M-phase inducer phosphatase 1 Ligustilide A tumor Siwu decoction
Muscarinic acetylcholine receptor M2 Snake bed lactone central nervous system disease Siwu decoction
Sodium/glucose cotransporter 1 Rehmapicroside diabetes mellitus Siwu decoction
Transcriptional activator protein LasR Senkyunolide J tumor Siwu decoction
Transient receptor potential cation channel subfamily A member 1 Dimethyl phthalate neuroglioma Siwu decoction
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