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Table 4 The predicted targets of partly components of Danshen and Siwu decoction. Danshen

From: Comparative study of Danshen and Siwu decoction based on the molecular structures of the components and predicted targets

Target

Compoud

Disease

Source

Acetylcholinesterase

Tanshinaldehyde

Alzheimer’s disease

Danshen

Aldose reductase

Rosmarinic acid

diabetes mellitus

Danshen

Bcl-2-related protein EAT/mcl1

Neotanshinone A

leucocythemia

Danshen

Bile acid receptor

przewalskin A

cardiovascular disease, liver disease

Danshen

Carbonic anhydrase 2

Protocatechuic acid

tumour

Danshen

Cocaine esterase

Tanshinone II A Sodium Sulfonate

detoxification of xenobiotics and in the activation of ester and amide prodrugs

Danshen

Carbonic anhydrase

3-lactamide

tumor

Danshen

DNA topoisomerase 2

Trijuganone A

tumor

Danshen

M18 aspartyl aminopeptidase

Prolithospermic acid

parasitic disease

Danshen

Sex hormone-binding globulin

przewalskin B

diabetes mellitus

Danshen

TrpV4

3-Oxoisotaxodione

cardiovascular disease

Danshen

Adenosine receptor A1

Adenosine

central nervous system disease

Siwu decoction

Alpha-glucosidase, Glucoamylase

paeonin

hyperglycemia

Siwu decoction

Carbonic anhydrase 9

East terpene lactone

tumor

Siwu decoction

Cathepsin B

Leucine

tumor

Siwu decoction

Epidermal growth factor receptor

Vanillin

tumor

Siwu decoction

Integrin beta-1

Tyrosine

tumor

Siwu decoction

M-phase inducer phosphatase 1

Ligustilide A

tumor

Siwu decoction

Muscarinic acetylcholine receptor M2

Snake bed lactone

central nervous system disease

Siwu decoction

Sodium/glucose cotransporter 1

Rehmapicroside

diabetes mellitus

Siwu decoction

Transcriptional activator protein LasR

Senkyunolide J

tumor

Siwu decoction

Transient receptor potential cation channel subfamily A member 1

Dimethyl phthalate

neuroglioma

Siwu decoction