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Table 7 Fractional inhibitory concentration (FIC) and FIC indices (FICi)

From: Synergistic antifungal evaluation of over-the-counter antifungal creams with turmeric essential oil or Aloe vera gel against pathogenic fungi

FIC aFICi/interpretation C. tropicalis (ATCC 66029) C. albicans P. notatum A. fumigatus A. niger A. flavus T. rubrum T. violceum T. mentagrophytes
Clotrimazole 0.60 0.25 0.80 0.50 0.40 0.80 0.30 0.25 0.30
TEO 0.60 0.25 0.40 0.50 0.20 0.40 0.60 0.50 0.30
FICi 1.20/ind 0.50/syn 1.20/ind 1.00/ind 0.60/ind 1.20/ind 0.90/ind 0.75/ind 0.60/ind
Fluconazole 0.40 0.60 0.80 0.50 0.60 0.50 0.30 0.20 0.25
TEO 0.40 0.30 0.40 0.50 0.30 0.50 0.60 0.40 0.50
FICi 0.80/ind 0.90/ind 1.20/ind 1.00/ind 0.90/ind 1.00/ind 0.90/ind 0.60/ind 0.75/ind
Ketoconazole 0.40 0.40 0.30 0.30 0.25 0.25 0.30 0.50 0.60
TEO 0.80 0.20 0.30 0.60 0.25 0.50 0.30 0.50 0.60
FICi 1.20/ind 0.60/ind 0.60/ind 0.90/ind 0.50/syn 0.75/ind 0.60/ind 1.00/ind 1.20/ind
Terbinafine 0.30 0.20 0.40 0.40 0.60 1.20 1.00 0.80 0.40
TEO 1.20 0.20 0.20 0.20 0.15 0.30 0.50 0.20 0.40
FICi 1.50/ind 0.40/syn 0.60/ind 0.60/ind 0.75/ind 1.50/ind 1.50/ind 1.00/ind 0.80/ind
Clotrimazole 0.40 0.10 0.40 0.30 0.20 0.60 0.15 0.10 0.40
AVG 0.40 0.20 0.40 0.30 0.40 0.30 0.60 0.80 0.80
FICi 0.80/ind 0.30/syn 0.80/ind 0.60/ind 0.60/ind 0.90/ind 0.75/ind 0.90/ind 1.20/ind
Fluconazole 0.60 0.50 0.40 0.30 0.50 0.20 0.15 0.20 0.20
AVG 0.60 0.50 0.40 0.30 1.00 0.20 0.60 1.60 0.80
FICi 1.20/ind 1.00/ind 0.80/ind 0.60/ind 1.50/ind 0.40/syn 0.75/ind 1.80/ind 1.00/ind
Ketoconazole 0.20 0.40 0.30 0.25 0.15 0.20 0.50 0.30 0.40
AVG 0.40 0.40 0.60 0.50 0.60 0.40 1.00 1.20 0.80
FICi 0.60/ind 0.80/ind 0.90/ind 0.75/ind 0.75/ind 0.60/ind 1.50/ind 1.50/ind 1.20/ind
Terbinafine 0.10 0.20 0.60 0.40 0.60 1.20 1.00 1.60 0.30
AVG 0.40 0.40 0.60 0.20 0.60 0.30 1.00 1.60 0.60
FICi 0.50/syn 0.60/ind 1.20/ind 0.60/ind 1.20/ind 1.50/ind 2.00/ind 3.20/ind 0.90/ind
  1. syn Synergetic, ind Indifferent
  2. aBold indicates Fractional Inhibitory Concentration index (FICi) / their interpretation