Protective effect of 6-paradol in acetic acid-induced ulcerative colitis in rats

Table 2 Effect of 6-paradol on Colon MPO and MDA, Serum MDA and IL-6, in acetic acid- induced colitis rats

Parameter	Group [Mean ± SEM (95%CI)]; Mean Rank (*Italics*)						Kruskal-Wallis H	p
Parameter	Normal Control (NC)	Acetic acid induced colitis: Untreated (AC)	Sulfasalazine treated (500 mg/kg) (SG)	6-paradol (50 mg/kg) (LT)	6-paradol (100 mg/kg) (MT)	6-paradol (200 mg/kg) (HT)	Kruskal-Wallis H	p
Colonic MPO^a,b (unit/g)	12.28 ± 0.44 (11.24, 13.32)	49.80 ± 1.61 (45.97, 53.62)	16.020 ± 0.66 (14.61, 17.78)	41.56 ± 1.14 (38.85, 44.26)	26.26 ± 0.88 (24.16, 28.35)	17.58 ± 0.75 (15.80, 19.37)	44.35	0.001
Colonic MPO^a,b (unit/g)	4.50	44.00	14.81	37.00	28.50	18.19	44.35	0.001
Colonic MDA^a,b (mmol/mg)	16.90 ± 0.49 (15.73, 18.06)	44.20 ± 1.68 (40.20, 48.19)	17.57 ± 0.77 (15.74, 19.40)	36.17 ± 0.81 (34.25, 38.09)	25.57 ± 0.88 (23.49, 27.65)	18.27 ± 0.98 (15.95, 20.59)	40.46	0.001
Colonic MDA^a,b (mmol/mg)	10.56	44.13	12.81	36.88	28.44	14.19	40.46	0.001
Serum IL-6^a,b,c (pg/ml)	12.01 ± 0.31 (11.25, 12.74)	41.53 ± 1.11 (38.90, 44.16)	12.93 ± 0.40 (11.98, 13.89)	35.57 ± 1.54 (31.92, 39.22)	25.86 ± 0.74 (24.11, 27.61)	14.71 ± 0.78 (12.85, 16.56)	42.30	0.001
Serum IL-6^a,b,c (pg/ml)	7.19	43.75	12.25	37.00	28.75	18.06	42.30	0.001
Serum MDA^a,b,c (nmol/l)	21.96 ± 0.75 (20.17, 23.75)	84.35 ± 2.03 (79.53, 89.16)	22.27 ± 0.66 (20.70, 23.84)	68.61 ± 1.76 (64.43, 72.78)	47.50 ± 2.29 (42.07, 52.92)	26.61 ± 0.85 (24.59, 28.62)	43.23	0.001
Serum MDA^a,b,c (nmol/l)	9.31	44.25	8.81	36.75	28.50	19.38	43.23	0.001

Legend: Effects of 6-paradol in different doses on colon MPO, colon MDA, serum MDA, and serum IL-6 in acetic acid-induced colitis rats, analysed by the Kruskal-Wallis H test followed by pairwise comparison; ^asignificant difference with AC (All parameters). ^bsignificant difference with NC (All parameters); ^cLT vs MT; MT vs HT for serum IL-6 and serum MDA; NC Normal control, AC Acetic acid-induced colitis untreated, SG Sulfasalazine treated (500 mg/kg), LT Low-dose 6-paradol (50 mg/kg), MT Medium-dose 6-paradol (100 mg/kg), HT High-dose 6-paradol (200 mg/kg), MPO Myeloperoxidase, MDA Malondialdehyde, IL Interleukin

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